ID   UVRC_BRADU              Reviewed;         686 AA.
AC   Q89DG9;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=blr7470;
OS   Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 /
OS   NBRC 14792 / USDA 110).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bradyrhizobiaceae; Bradyrhizobium.
OX   NCBI_TaxID=224911;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110;
RX   PubMed=12597275; DOI=10.1093/dnares/9.6.189;
RA   Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S.,
RA   Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M.,
RA   Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S.;
RT   "Complete genomic sequence of nitrogen-fixing symbiotic bacterium
RT   Bradyrhizobium japonicum USDA110.";
RL   DNA Res. 9:189-197(2002).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; BA000040; BAC52735.1; -; Genomic_DNA.
DR   RefSeq; NP_774110.1; NC_004463.1.
DR   RefSeq; WP_011090203.1; NZ_CP011360.1.
DR   AlphaFoldDB; Q89DG9; -.
DR   SMR; Q89DG9; -.
DR   STRING; 224911.27355753; -.
DR   EnsemblBacteria; BAC52735; BAC52735; BAC52735.
DR   GeneID; 64027227; -.
DR   KEGG; bja:blr7470; -.
DR   PATRIC; fig|224911.44.peg.7569; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_0_5; -.
DR   InParanoid; Q89DG9; -.
DR   OMA; HIECFDN; -.
DR   PhylomeDB; Q89DG9; -.
DR   Proteomes; UP000002526; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IBA:GO_Central.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..686
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000264875"
FT   DOMAIN          81..160
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          270..305
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   REGION          1..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..22
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   686 AA;  76253 MW;  06BD0EF38BFE6ACB CRC64;
     MVHDSTDDPD DTRVRKSRRG TALDAPPQET APPDLDPATT GGDDEDDALL PDILEESGAV
     GEEPLASGHE AIERAVRLAP TSPGVYRMLN ANADVLYVGK AKNVKKRLSN YARQSAPQPA
     RILRMIAATV TVEIVSTNTE TEALLLEANL IKQLRPRFNV QLRDDKSFPY ILITGDHWAP
     QILKHRGAQT RPGRYFGPFA SAGAVNRTIT ALQRAFLIRS CTDSFFESRS RPCLLYQIRR
     CAGPCTREID FPGYTTLVRE ATDFLSGKSH AVKQELAGEM EKAANELEFE TAALYRDRLA
     ALSAIQSQQG INPRTVEEAD VFAIHQEGGF SCVEVFFFRT GQNWGNRAYF PRAEKTFTPE
     EVLGSFLAQF YDDKPPPKNI LLSHEIEESE LLANALSIKA GHKIEVTAPK RGEKKELVAH
     ALTNAREALG RKLADTATQG RLLDAMATTL SLPHAPKRIE VYDNSHIQGT NAVGAMIVAG
     PDGFVKNQYR KFNIKSEGLT PGDDYGMMRE VLERRFKRLI NPPEEGAKVK DDDFPQWPDL
     VIIDGGRGQL NAVREIFANL GLTQVSLMSV AKGPDRDAGR ETLFMPEREA IKLEPRDPVL
     YFIQRLRDEA HRFVIGSHRK LRKKDIREAG LQEIPGIGPS RKRALLHHFG TLKEIERASI
     ADLGKVPGVS AESARRIFEY FHPQPG