ID   UVRC_BURCM              Reviewed;         684 AA.
AC   Q0BGZ5;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=Bamb_1019;
OS   Burkholderia ambifaria (strain ATCC BAA-244 / AMMD) (Burkholderia cepacia
OS   (strain AMMD)).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX   NCBI_TaxID=339670;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-244 / AMMD;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Pitluck S., Bruce D., Chain P.,
RA   Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Kim E., Parke J., Coenye T., Konstantinidis K.,
RA   Ramette A., Tiedje J., Richardson P.;
RT   "Complete sequence of chromosome 1 of Burkholderia cepacia AMMD.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CP000440; ABI86578.1; -; Genomic_DNA.
DR   RefSeq; WP_011656361.1; NZ_CP009798.1.
DR   AlphaFoldDB; Q0BGZ5; -.
DR   SMR; Q0BGZ5; -.
DR   STRING; 339670.Bamb_1019; -.
DR   EnsemblBacteria; ABI86578; ABI86578; Bamb_1019.
DR   GeneID; 44691702; -.
DR   KEGG; bam:Bamb_1019; -.
DR   PATRIC; fig|339670.21.peg.553; -.
DR   eggNOG; COG0322; Bacteria.
DR   OMA; HIECFDN; -.
DR   Proteomes; UP000000662; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   SOS response.
FT   CHAIN           1..684
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_1000077758"
FT   DOMAIN          22..100
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          209..244
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   684 AA;  74548 MW;  930BFBACDCBA0A32 CRC64;
     MTSPEAVDIP FEPKKILAQL PHMPGVYRYY DTAGAVLYVG KARDLKKRVS SYFTKTQLSP
     RIAMMVTRIA RIETTVTRSE AEALLLENNL IKALAPRYNI LFRDDKSYPY LKLTAHRFPR
     MAYYRGSVDK QNQYFGPFPS AWAVRESIQI LQRVFQLRTC EDSVFNNRTR PCLLHQIGRC
     TAPCVGAISA DDYAIDVSNA ARFLLGRQSE VMKELEQKMH AFAAELKFEQ AAAVRNQMSS
     LATVLHQQAI EVGSDSDVDI LAVVAQGGRV CVNLAMVRGG RHLGDKAYFP AHVESALTLA
     EGGLGDEADG ADGADEAAAA LPGEPADEAA AARDAASSAS GASSASVEAE VLDAFIAQHY
     LGNRVPPVLV VSHAPASRDL LELLSEQAGH KVSLVRQPQG QRRAWLSMAE QNARLALARL
     LSEQGSQQAR TRALAETLSF ECDDLAMLRI ECFDISHTMG EATQASCVVY HHHKMQSGEY
     RRYNITGITP GDDYAAMRQV LTRRYEKMVE QAAQAAAADA AAGIDGESTR EAEASSLLPN
     IVLIDGGKGQ VEIARQVFTE LGLDTSMLVG VAKGEGRKVG LETLVFADGR TPLELGKESA
     ALMLVAQIRD EAHRFAITGM RAKRAKARQT SRLEELEGIG AKRRQRLLAR FGGLRGVVAA
     SVEELASVEG ISHALAEQIY KQLH