CAF17_YEAST
ID CAF17_YEAST Reviewed; 497 AA.
AC P47158; D6VWU1;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Putative transferase CAF17, mitochondrial;
DE EC=2.1.-.-;
DE AltName: Full=57 kDa iron-sulfur cluster assembly factor for biotin synthase- and aconitase-like mitochondrial proteins;
DE AltName: Full=CCR4-associated factor 17;
DE Flags: Precursor;
GN Name=IBA57; Synonyms=CAF17; OrderedLocusNames=YJR122W; ORFNames=J2043;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8641269; DOI=10.1002/j.1460-2075.1996.tb00557.x;
RA Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C.,
RA Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D.,
RA Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J.,
RA Heumann K., Hilger F., Hollenberg C.P., Huang M.-E., Jacq C.,
RA Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E.,
RA Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T.,
RA Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B.,
RA Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R.,
RA Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N.,
RA To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H.,
RA von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.;
RT "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.";
RL EMBO J. 15:2031-2049(1996).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP INDUCTION.
RX PubMed=12161108; DOI=10.1016/s0143-4160(02)00110-0;
RA Lombardia L.J., Becerra M., Rodriguez-Belmonte E., Hauser N.C.,
RA Cerdan M.E.;
RT "Genome-wide analysis of yeast transcription upon calcium shortage.";
RL Cell Calcium 32:83-91(2002).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [5]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [6]
RP INTERACTION WITH CCR4.
RX PubMed=14734555; DOI=10.1074/jbc.m313202200;
RA Clark L.B., Viswanathan P., Quigley G., Chiang Y.-C., McMahon J.S., Yao G.,
RA Chen J., Nelsbach A., Denis C.L.;
RT "Systematic mutagenesis of the leucine-rich repeat (LRR) domain of CCR4
RT reveals specific sites for binding to CAF1 and a separate critical role for
RT the LRR in CCR4 deadenylase activity.";
RL J. Biol. Chem. 279:13616-13623(2004).
RN [7]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RX PubMed=16823961; DOI=10.1021/pr050477f;
RA Reinders J., Zahedi R.P., Pfanner N., Meisinger C., Sickmann A.;
RT "Toward the complete yeast mitochondrial proteome: multidimensional
RT separation techniques for mitochondrial proteomics.";
RL J. Proteome Res. 5:1543-1554(2006).
RN [8]
RP FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH ISA1 AND ISA2.
RX PubMed=18086897; DOI=10.1128/mcb.01963-07;
RA Gelling C., Dawes I.W., Richhardt N., Lill R., Muehlenhoff U.;
RT "Mitochondrial Iba57p is required for Fe/S cluster formation on aconitase
RT and activation of radical SAM enzymes.";
RL Mol. Cell. Biol. 28:1851-1861(2008).
CC -!- FUNCTION: Required for lysine and glutamate prototrophy and
CC mitochondrial genome maintenance. Has a role in the maturation of
CC mitochondrial aconitase-type and radical-SAM Fe/S proteins biotin
CC synthase and lipoic acid synthase. {ECO:0000269|PubMed:18086897}.
CC -!- SUBUNIT: Interacts with CCR4, ISA1 and ISA2.
CC {ECO:0000269|PubMed:14734555, ECO:0000269|PubMed:18086897}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:16823961,
CC ECO:0000269|PubMed:18086897}.
CC -!- INDUCTION: Up-regulated during calcium shortage.
CC {ECO:0000269|PubMed:12161108}.
CC -!- MISCELLANEOUS: Present with 2960 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the GcvT family. CAF17 subfamily. {ECO:0000305}.
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DR EMBL; Z49622; CAA89653.1; -; Genomic_DNA.
DR EMBL; BK006943; DAA08907.1; -; Genomic_DNA.
DR PIR; S57145; S57145.
DR RefSeq; NP_012656.1; NM_001181780.1.
DR AlphaFoldDB; P47158; -.
DR SMR; P47158; -.
DR BioGRID; 33878; 18.
DR DIP; DIP-1404N; -.
DR IntAct; P47158; 13.
DR MINT; P47158; -.
DR STRING; 4932.YJR122W; -.
DR MaxQB; P47158; -.
DR PaxDb; P47158; -.
DR PRIDE; P47158; -.
DR EnsemblFungi; YJR122W_mRNA; YJR122W; YJR122W.
DR GeneID; 853586; -.
DR KEGG; sce:YJR122W; -.
DR SGD; S000003883; IBA57.
DR VEuPathDB; FungiDB:YJR122W; -.
DR eggNOG; KOG2929; Eukaryota.
DR GeneTree; ENSGT00390000006465; -.
DR HOGENOM; CLU_007884_7_3_1; -.
DR InParanoid; P47158; -.
DR OMA; LCRLEVM; -.
DR BioCyc; YEAST:G3O-31743-MON; -.
DR PRO; PR:P47158; -.
DR Proteomes; UP000002311; Chromosome X.
DR RNAct; P47158; protein.
DR GO; GO:0005759; C:mitochondrial matrix; IDA:SGD.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IBA:GO_Central.
DR GO; GO:0106034; P:protein maturation by [2Fe-2S] cluster transfer; IMP:SGD.
DR GO; GO:0106035; P:protein maturation by [4Fe-4S] cluster transfer; IMP:SGD.
DR Gene3D; 3.30.1360.120; -; 1.
DR InterPro; IPR027266; TrmE/GcvT_dom1.
DR InterPro; IPR045179; YgfZ/GcvT.
DR InterPro; IPR017703; YgfZ/GcvT_CS.
DR PANTHER; PTHR22602; PTHR22602; 1.
DR TIGRFAMs; TIGR03317; ygfZ_signature; 1.
PE 1: Evidence at protein level;
KW Mitochondrion; Reference proteome; Transferase; Transit peptide.
FT TRANSIT 1..27
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 28..497
FT /note="Putative transferase CAF17, mitochondrial"
FT /id="PRO_0000203117"
FT REGION 414..433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 497 AA; 57055 MW; A9970EBD3BF6019C CRC64;
MFISRRCRIK GFTLKNLLWF RSSSTRFVST ESPDASAITK PDGIFNYSLL ENRTYIRIRG
PDTVKFLNGL VTSKLLPHFI KKNLTTVEEN EVPTEEGTTK VDPIIPVPEF DARLGNWGLY
NEKGIQGPYI SRFGLYSAFL NGKGKLITDT IIYPTPVTVS EQISNYPEYL LELHGNVVDK
ILHVLQTHKL ANKIKFEKID HSSLKTWDVE VQFPNLPKDI ENPWFDNLLD PMALPKNSID
ANNFAVNVLN SLFNSDPRIL GIYVERRTES MSRHYSTFPQ SFRVVTSEQV DDLSKLFNFN
VFDFPFQVNK KASVQVREIR FQKGLIDSTE DYISETLLPL ELNFDFFPNT ISTNKGCYVG
QELTARTYAT GILRKRLVPV KLDNYQLLDT DPERKYAEFH IDNVVEKSLA ENEPTLNPFT
NKPPERTKRK QRPAGLLISN EGLYGVALLR TEHFSAAFSS DEPVEFYITT TKGENIKITP
QKPFWFSDWK NNNGPHK
