ID   UVRC_CAMJE              Reviewed;         600 AA.
AC   Q9PN51; Q0P910;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=Cj1246c;
OS   Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC
OS   11168).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Campylobacteraceae; Campylobacter.
OX   NCBI_TaxID=192222;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700819 / NCTC 11168;
RX   PubMed=10688204; DOI=10.1038/35001088;
RA   Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M.,
RA   Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S.,
RA   Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A.,
RA   Rajandream M.A., Rutherford K.M., van Vliet A.H.M., Whitehead S.,
RA   Barrell B.G.;
RT   "The genome sequence of the food-borne pathogen Campylobacter jejuni
RT   reveals hypervariable sequences.";
RL   Nature 403:665-668(2000).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; AL111168; CAL35361.1; -; Genomic_DNA.
DR   PIR; H81331; H81331.
DR   RefSeq; WP_002864614.1; NC_002163.1.
DR   RefSeq; YP_002344637.1; NC_002163.1.
DR   AlphaFoldDB; Q9PN51; -.
DR   SMR; Q9PN51; -.
DR   IntAct; Q9PN51; 5.
DR   STRING; 192222.Cj1246c; -.
DR   PaxDb; Q9PN51; -.
DR   PRIDE; Q9PN51; -.
DR   EnsemblBacteria; CAL35361; CAL35361; Cj1246c.
DR   GeneID; 905537; -.
DR   KEGG; cje:Cj1246c; -.
DR   PATRIC; fig|192222.6.peg.1228; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_2_7; -.
DR   OMA; HIECFDN; -.
DR   Proteomes; UP000000799; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..600
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000227408"
FT   DOMAIN          15..100
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          203..238
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   600 AA;  69694 MW;  D9F93DC237A3A5AA CRC64;
     MTKENLENEL KTLPNSTGVY QYFNQEGKLL YVGKAKNLKN RVRSYFAFTP NLHANPRNSL
     RIQKMIEETV HLEFIATNSE ADALILENSF IKQLHPKYNI LLRDDKTYPY IYVDFEEEFP
     RFEITRKLVK KSKIKYFGPF FKGARELLDA LYLYYPLKQK ASCKSPCIFY QISRCLAPCD
     KLISREKYLE ILDEAIHALL NPSVLLKNLE KQMLVLAQNE NYEEAAKVRD QIAMIKDLEV
     KVEIDIAKLE DFEVFALAFK NSVLSTLRFV VQNGKIISAN SKITPIKNDI QWDQNEIYKQ
     LILENFSMDI PLLANVIYVY EEFEDRVLLE EILSQRFDKK ISIKIPKIGE KRRICDLAFQ
     NALLNIEKEQ KNHDFTIQKE LKSYFELENL PNDIEIFDNS HLQGVANVGA MVTYRINSWD
     KSKYRKFHLK HKNDYDQMRE VLTRRALDFD KIPPPDLWLI DGGKALLDLA KEIIVSSGVN
     VDILAISKEK IDAKAHRAKG GAKDKIHSLK GEFSLSINDK KLQFLQKLRD EAHRFAISFH
     QNTKKKQDLK SSKLANLGLS SGVMQKLLAY YGNFESIYKA DFKDLTMLVG RKAAQKIKEN