ID   UVRC_CAMJJ              Reviewed;         600 AA.
AC   A1W0N0;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203};
GN   OrderedLocusNames=CJJ81176_1261;
OS   Campylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Campylobacteraceae; Campylobacter.
OX   NCBI_TaxID=354242;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=81-176;
RA   Fouts D.E., Nelson K.E., Sebastian Y.;
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CP000538; EAQ72503.1; -; Genomic_DNA.
DR   RefSeq; WP_002869075.1; NC_008787.1.
DR   AlphaFoldDB; A1W0N0; -.
DR   SMR; A1W0N0; -.
DR   STRING; 354242.CJJ81176_1261; -.
DR   EnsemblBacteria; EAQ72503; EAQ72503; CJJ81176_1261.
DR   KEGG; cjj:CJJ81176_1261; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_2_7; -.
DR   OMA; HRFAQHY; -.
DR   Proteomes; UP000000646; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   SOS response.
FT   CHAIN           1..600
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_1000077767"
FT   DOMAIN          15..100
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          203..238
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   600 AA;  69789 MW;  2E08134115A8891B CRC64;
     MTKENLENEL KTLPNSAGVY QYFNQEGKLL YVGKAKNLKN RVKSYFAFTP NLHANPRNSL
     RIQKMIEETV HLEFITTNSE ADALILENSF IKQLHPKYNI LLRDDKTYPY IYVNFEEEFP
     RFEITRKLVK KSKIKYFGPF FKGARELLDA LYLYYPLKQK ASCKSPCIFY QISRCLAPCD
     KRISKEKYLE ILDEAMHALL NPSILIKNLE KQMLVLAQNE NYEEAAKVRD QIVTIKDLEV
     KVEMDVAKLE DFEVFALAFE DSMLSTLRFV VQNGKIISAN SKITPIKNDI QWDQNEIYKQ
     LILENFSMDI PLLANVIYVY EEFEDRVLLE EILSQRFDKK ISIKIPKIGE KRRICDLAFQ
     NALLNIEKEQ KNHDFTIQKE LKFYFELENL PNDIEIFDNS HLQGVANVGA MVTYRINSWD
     KSKYRKFHLK HKNDYDQMRE VLTRRALDFD KIPPPDLWLI DGGKVLLDLA KKIIVSSGAN
     VDILAISKEK IDAKAHRAKG GAKDKIHSLK GEFSLSINDK KLQFLQKLRD EAHRFAISFH
     QNTKKKQDLK SSKLANLGLS SGVIQKLLAY YGNFESIYKA DFKDLTMLVG RKAAQKIKEN