ID   UVRC_CAUVC              Reviewed;         640 AA.
AC   Q9A4F3;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=CC_2881;
OS   Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter.
OX   NCBI_TaxID=190650;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19089 / CB15;
RX   PubMed=11259647; DOI=10.1073/pnas.061029298;
RA   Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E.,
RA   Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R.,
RA   Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B.,
RA   DeBoy R.T., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F.,
RA   Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R.,
RA   Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O.,
RA   Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M.;
RT   "Complete genome sequence of Caulobacter crescentus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; AE005673; AAK24845.1; -; Genomic_DNA.
DR   PIR; A87606; A87606.
DR   RefSeq; NP_421677.1; NC_002696.2.
DR   RefSeq; WP_010920721.1; NC_002696.2.
DR   AlphaFoldDB; Q9A4F3; -.
DR   SMR; Q9A4F3; -.
DR   STRING; 190650.CC_2881; -.
DR   EnsemblBacteria; AAK24845; AAK24845; CC_2881.
DR   KEGG; ccr:CC_2881; -.
DR   PATRIC; fig|190650.5.peg.2885; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_0_5; -.
DR   OMA; HIECFDN; -.
DR   BioCyc; CAULO:CC2881-MON; -.
DR   Proteomes; UP000001816; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; EXP:CollecTF.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..640
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000227411"
FT   DOMAIN          35..113
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          223..258
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   640 AA;  70839 MW;  47E4B331970B4AD5 CRC64;
     MTDTPSASDA EAPLRQAAPL WGAALIKDEV TRLPDAPGVY RMIGEADEVL YVGKAKSLKK
     RVVQYAQGRF HTNRIANMVD ATRAMEFITT RTEADALLLE INLIKQLKPR FNVLLRDDKS
     FPEIVIRRDH DAPQLRKHRG AHTIKGDYFG PFASAWAVNR TLNTLQKAFL LRSCSDSVYD
     SRDRPCMLYQ IKRCAAPCTG LIGKDDYQAL VDQAEAFLRG KSRAVMATMA KAMEEAAEEL
     EFERAARLRD RIRALSAVAQ ETQINPETVE EADVVALHVE GGQACVQVFF FRAGQNWGNR
     AYFPRITGAA DDPEDETVTE EQRIITAFLG QFYDDKPIPR LILANVQPAE SELLSEAFAL
     KSGRKVEIAV PKRGEKADLV QHVLTNAREA LGRKMAEGSA QTKLLAGVAE AFKLDAPPER
     IEVYDNSHIQ GANAVGGMIV AGPEGFMKGQ YRKFNIKSTE LTPGDDYGMM KEVLRRRFAR
     LVKEEEEGDD ANRPDLVLVD GGQGQLDAAI EIMADLGVDD IAVVGVAKGP DRDAGLERFF
     IPGQTPFMLE PKSPVLYYLQ RLRDEAHRFA IGAHRTRRSM DLKKNPLDEI EGVGPGRKKA
     LLHAFGSAKG VGRASVEDLV KVDGVSQALA ERIFGFFRKG