ID   UVRC_CERS4              Reviewed;         623 AA.
AC   Q3IYX6;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=RHOS4_26900;
GN   ORFNames=RSP_1074;
OS   Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG
OS   31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.) (Rhodobacter
OS   sphaeroides).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Cereibacter.
OX   NCBI_TaxID=272943;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203
RC   / NCIMB 8253 / ATH 2.4.1.;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C.,
RA   Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J., Kaplan S.;
RT   "Complete sequence of chromosome 1 of Rhodobacter sphaeroides 2.4.1.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CP000143; ABA80258.1; -; Genomic_DNA.
DR   RefSeq; WP_011338696.1; NZ_CP030271.1.
DR   RefSeq; YP_354159.1; NC_007493.2.
DR   AlphaFoldDB; Q3IYX6; -.
DR   SMR; Q3IYX6; -.
DR   STRING; 272943.RSP_1074; -.
DR   EnsemblBacteria; ABA80258; ABA80258; RSP_1074.
DR   GeneID; 67447848; -.
DR   KEGG; rsp:RSP_1074; -.
DR   PATRIC; fig|272943.9.peg.3048; -.
DR   eggNOG; COG0322; Bacteria.
DR   OMA; HIECFDN; -.
DR   PhylomeDB; Q3IYX6; -.
DR   Proteomes; UP000002703; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR041663; DisA/LigA_HHH.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF12826; HHH_2; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..623
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000227468"
FT   DOMAIN          27..105
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          215..250
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   623 AA;  68736 MW;  8ADA67B6BD55498A CRC64;
     MQDNETDGRD VPTGHAVIQG YLKTLDGSPG VYRMLDAQSQ VLYVGKARNL RARVSNYARP
     SGHSGRIARM IRETASMMFL TTRTETEALL LEQNLIKQLK PRYNVLLRDD KSFPNILIAK
     DHPFPMLKKH RGKKSEKGSY FGPFASAGAV NRTLNQLQRV FLLRTCSDAT FESRTRPCLL
     FQIKRCSAPC VGRVPAEDYA ELIGDAERFL QGRTTKVQAN LAEQMQAASE AMEFERAAAL
     RDRIKALTQV QSSQGINPRG VAEADVIAVH LEGGQACVQV FFIRANQSWG NRDFFPRTGA
     GAEEPEILEA FLAQFYDDKE PPRMILLSHP VDNPDLVGQL LSERAGRKVT LGVPQRGEKA
     ELVENAARNA RESLARRMAE SATQNRLLAG LAEAFELDAA PKRIEVYDNS HIQGTNAVGG
     MIVAGPEGFL KSQYRKFNIR GAAGAQGDDF GMMKEVLTRR FERLLKEDPE RKTDAWPDLL
     LIDGGAGQVS AVQEILQELG VDDVPFIGVA KGIDRDAGKE EFHRPGEPPF ALRMNDPVLY
     FVQRLRDEAH RWAIGAHRAK RAKAVSATPL DEIPGVGAAR KRALLAHFGS AKAVARAGVP
     DLCAVEGISE TMAQSIHDYF HGS