UVRC_CHLPN
ID UVRC_CHLPN Reviewed; 603 AA.
AC Q9Z6W6; Q9JQA6;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 133.
DE RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203};
GN OrderedLocusNames=CPn_0940, CP_0921, CpB0974;
OS Chlamydia pneumoniae (Chlamydophila pneumoniae).
OC Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC Chlamydia/Chlamydophila group; Chlamydia.
OX NCBI_TaxID=83558;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CWL029;
RX PubMed=10192388; DOI=10.1038/7716;
RA Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W.,
RA Olinger L., Grimwood J., Davis R.W., Stephens R.S.;
RT "Comparative genomes of Chlamydia pneumoniae and C. trachomatis.";
RL Nat. Genet. 21:385-389(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AR39;
RX PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O.,
RA Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S.,
RA Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J.,
RA Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G.,
RA Salzberg S.L., Eisen J.A., Fraser C.M.;
RT "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae
RT AR39.";
RL Nucleic Acids Res. 28:1397-1406(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J138;
RX PubMed=10871362; DOI=10.1093/nar/28.12.2311;
RA Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K.,
RA Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.;
RT "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from
RT Japan and CWL029 from USA.";
RL Nucleic Acids Res. 28:2311-2314(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TW-183;
RA Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P.,
RA Schneider S., Pohl T., Essig A., Marre R., Melchers K.;
RT "The genome sequence of Chlamydia pneumoniae TW183 and comparison with
RT other Chlamydia strains based on whole genome sequence analysis.";
RL Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC lesion. The N-terminal half is responsible for the 3' incision and the
CC C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC Rule:MF_00203}.
CC -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC {ECO:0000255|HAMAP-Rule:MF_00203}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC Rule:MF_00203}.
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DR EMBL; AE001363; AAD19078.1; -; Genomic_DNA.
DR EMBL; AE002161; AAF38706.1; -; Genomic_DNA.
DR EMBL; BA000008; BAA99148.1; -; Genomic_DNA.
DR EMBL; AE009440; AAP98903.1; -; Genomic_DNA.
DR PIR; B86608; B86608.
DR PIR; F72017; F72017.
DR RefSeq; NP_225135.1; NC_000922.1.
DR RefSeq; WP_010883575.1; NZ_LN847257.1.
DR AlphaFoldDB; Q9Z6W6; -.
DR SMR; Q9Z6W6; -.
DR STRING; 115711.CP_0921; -.
DR EnsemblBacteria; AAD19078; AAD19078; CPn_0940.
DR EnsemblBacteria; AAF38706; AAF38706; CP_0921.
DR GeneID; 45050996; -.
DR KEGG; cpa:CP_0921; -.
DR KEGG; cpj:uvrC; -.
DR KEGG; cpn:CPn_0940; -.
DR KEGG; cpt:CpB0974; -.
DR PATRIC; fig|115713.3.peg.1028; -.
DR eggNOG; COG0322; Bacteria.
DR HOGENOM; CLU_014841_3_2_0; -.
DR OrthoDB; 1036075at2; -.
DR Proteomes; UP000000583; Chromosome.
DR Proteomes; UP000000801; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.420.340; -; 1.
DR Gene3D; 3.40.1440.10; -; 1.
DR HAMAP; MF_00203; UvrC; 1.
DR InterPro; IPR000305; GIY-YIG_endonuc.
DR InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR001943; UVR_dom.
DR InterPro; IPR036876; UVR_dom_sf.
DR InterPro; IPR004791; UvrC.
DR InterPro; IPR001162; UvrC_RNase_H_dom.
DR InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR Pfam; PF01541; GIY-YIG; 1.
DR Pfam; PF08459; UvrC_HhH_N; 1.
DR SMART; SM00465; GIYc; 1.
DR SUPFAM; SSF46600; SSF46600; 1.
DR SUPFAM; SSF47781; SSF47781; 1.
DR SUPFAM; SSF82771; SSF82771; 1.
DR TIGRFAMs; TIGR00194; uvrC; 1.
DR PROSITE; PS50164; GIY_YIG; 1.
DR PROSITE; PS50151; UVR; 1.
DR PROSITE; PS50165; UVRC; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW SOS response.
FT CHAIN 1..603
FT /note="UvrABC system protein C"
FT /id="PRO_0000138294"
FT DOMAIN 13..92
FT /note="GIY-YIG"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT DOMAIN 205..240
FT /note="UVR"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ SEQUENCE 603 AA; 69426 MW; 28017E4FA19FFC84 CRC64;
MRIEDFSLKL IPSSPGVYLM KDVHDQVLYI GKAKNLKNRL ASYFHEKGDS RERIPFLMKK
TASIETIVVS NETEALLLEN NLIKQHHPKY NVLLKDDKTF FCLAISLSHS WPKVEAIRTK
AITSSQRQLI FGPYVSAEAC HTLLEVISQW FPLRTCSDRE FALRKRPCIL YDMKRCLAPC
VGYCTPEEYQ GTLDKAILFL KGKIEEVVKD LEKVIQKASD NLEFEQAANY YRTLSLIKQA
MAKQQVEKFH FQNIDALGLY RHKQRTILTL LTVRSGKLLG ARHFSFFENA QEDQDLLSSF
ILQYYVSQPY IPKEILTPLP LEFPTLSYVL NAESPPRLRS PKTGYGKELL DLAYRNAKAY
AATTLPSSTL PYQDFQNILR MSQYPYRIEC YDNAHMQGAH ATGVYIVFEN NGFDPKQYRT
FSIDSEKTQN DLALLEEVLL RRFHSLTTAL PDMIVVDGGK THYNKTKKII QTLNLTGIQV
VTIAKEKSNH SRGLNKEKIF CETFPEGFSL PPTSNLLQFF QILRDEAHRF AISKHRKKRG
KALFEQEKIP GIGEVKRKRL LQKFKSWKQV MLSSQEELEA IPGLTKKDIA VLLARQKDFN
KSD
