ID   UVRC_CHLTR              Reviewed;         598 AA.
AC   O84796;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 112.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=CT_791;
OS   Chlamydia trachomatis (strain D/UW-3/Cx).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=272561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=D/UW-3/Cx;
RX   PubMed=9784136; DOI=10.1126/science.282.5389.754;
RA   Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L.,
RA   Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.;
RT   "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia
RT   trachomatis.";
RL   Science 282:754-759(1998).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; AE001273; AAC68386.1; -; Genomic_DNA.
DR   PIR; C71471; C71471.
DR   RefSeq; NP_220310.1; NC_000117.1.
DR   RefSeq; WP_010725346.1; NC_000117.1.
DR   AlphaFoldDB; O84796; -.
DR   SMR; O84796; -.
DR   STRING; 813.O172_04405; -.
DR   EnsemblBacteria; AAC68386; AAC68386; CT_791.
DR   GeneID; 884594; -.
DR   KEGG; ctr:CT_791; -.
DR   PATRIC; fig|272561.5.peg.870; -.
DR   HOGENOM; CLU_014841_3_2_0; -.
DR   InParanoid; O84796; -.
DR   OMA; HIECFDN; -.
DR   Proteomes; UP000000431; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IBA:GO_Central.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..598
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000138296"
FT   DOMAIN          13..92
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          206..241
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   598 AA;  68561 MW;  58092A1F87FDA7CE CRC64;
     MRIEDFSLKD VSSSPGVYLM KDSQGTVLYV GKAKNLRNRL SSYLQKKGDS RKRIPFLMKK
     TTDIDTIVVS NETEAILLEN NLIKKYQPRY NVLLKDDKTF FCLSVSLEHP WPRIEAIRTR
     ALSPGKKKQW LFGPYVSAEA CYALLEVISL WFPLRTCSDR EFSTRQRPCV LYEMKRCLAP
     CVGLCSQTEY QETLDKAVLF LKGDVRSTIS NLEKAIEKAS QEQKFEHAAA LYRTLTLIRQ
     TMAKQHVEKF QAYDIDVLGL YRKGSLAIVS VLSVYSGKLL GARYFIFPEN AQEDSALFSS
     FILQYYAENP RIPKEIFVPV SLDSPELPYL LNTAEPPKIR CPKTEYGKEL LALAHKNAAE
     QAKPFNSITP PYEELQHFFN LSQYPYRIEC YDNAHLQGEH NVGVCIVFEN GLFSPKQYRT
     FSITSHGDDL AAFEEVLTRR FRSLTTELPN LIVIDGGRNQ FKRAQRILEE LNLTGITVVT
     IAKESGNHSK SLRQEKLFCE TFPQGILLHP TSAILQFFQL LRDEAHRFAI QHYRKKHAKA
     VLTTKKIPGI GEVKTKRLLQ KFKSWKRVFI ASEEELKTVQ GITAKDIQRI QEEGAKPE