ID   UVRC_CLOB6              Reviewed;         618 AA.
AC   C3KV13;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2009, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=CLJ_B3683;
OS   Clostridium botulinum (strain 657 / Type Ba4).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=515621;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=657 / Type Ba4;
RA   Shrivastava S., Brown J.L., Bruce D., Detter C., Munk C., Smith L.A.,
RA   Smith T.J., Sutton G., Brettin T.S.;
RT   "Genome sequence of Clostridium botulinum Ba4 strain 657.";
RL   Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CP001083; ACQ53747.1; -; Genomic_DNA.
DR   RefSeq; WP_003360285.1; NC_012658.1.
DR   AlphaFoldDB; C3KV13; -.
DR   SMR; C3KV13; -.
DR   EnsemblBacteria; ACQ53747; ACQ53747; CLJ_B3683.
DR   KEGG; cbi:CLJ_B3683; -.
DR   HOGENOM; CLU_014841_3_2_9; -.
DR   OMA; HIECFDN; -.
DR   Proteomes; UP000002333; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR041663; DisA/LigA_HHH.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF12826; HHH_2; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   SOS response.
FT   CHAIN           1..618
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_1000204116"
FT   DOMAIN          13..92
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          204..239
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   618 AA;  71614 MW;  636BA6E4A50EE14D CRC64;
     MFDLEYQLKN LPDKPGVYLM KNNLGEIIYV GKAKILKNRV RQYFQKSQKH SEKVKAMVKN
     IEEFEYIITD SEIEALILEC NLIKKYRPKY NILLKDDKHY PFIKVTLAED FPRVISTRKV
     TKDGSKYFGP YVDGSSVKDI IELIKKTFPI RTCKKNIVEG AKAIRPCLNY QIGLCKAPCA
     QYIKKSEYRE IIDDVIKLLS GKHLDIVENF KLNMEKAAGN LEFEKAAMLR DKINIIEKIG
     EKQKIILNNF DNEDYISLYS DGKDTCFQVF FLRNGKIVGR EHFIIEDTFD TNSSTLISNF
     LKEFYGGTAY IPKTIYVPNI EDEVLLEQWL TLKKESKSTI KIPIKGEKKN ILDLVEKNAK
     TTLENFKLKY LQEKALYDNV LKDLKNILRL QEEPIRIEAF DISNIQGFDS VGSMVVFEKG
     RAKPSDYRRF KINTVKGADD YKSMKEILTR RFQHGLSEIK SIQDRKLEFS SGKFSVFPDL
     ILMDGGKGQI NIALEVLNTF NINIPVCGMV KDNKHRTRGL IYNGEEIIIN KYGSVMKFIT
     RVQDEVHRFA ISYHRSLRGK NSFHSLLDDI PNIGEKRKKD LLFNFKSIDN IKKATYEELL
     SISSMDKKSA ESILEFFK