CAF1A_DANRE
ID CAF1A_DANRE Reviewed; 863 AA.
AC A0JMK9; Q1LYI1;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 12-DEC-2006, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Chromatin assembly factor 1 subunit A;
DE Short=CAF-1 subunit A;
DE AltName: Full=Chromatin assembly factor I p150 subunit;
DE Short=CAF-I 150 kDa subunit;
DE Short=CAF-I p150;
GN Name=chaf1a; Synonyms=caip150; ORFNames=ch211-129c21.3, zgc:153930;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-111 AND SER-118, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18307296; DOI=10.1021/pr700667w;
RA Lemeer S., Pinkse M.W.H., Mohammed S., van Breukelen B., den Hertog J.,
RA Slijper M., Heck A.J.R.;
RT "Online automated in vivo zebrafish phosphoproteomics: from large-scale
RT analysis down to a single embryo.";
RL J. Proteome Res. 7:1555-1564(2008).
CC -!- FUNCTION: May be involved in chromatin assembly in DNA replication and
CC DNA repair. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q13111}. Note=DNA
CC replication foci. {ECO:0000250|UniProtKB:Q13111}.
CC -!- SIMILARITY: Belongs to the CHAF1A family. {ECO:0000305}.
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DR EMBL; BX005201; CAK04065.1; -; Genomic_DNA.
DR EMBL; BC125916; AAI25917.1; -; mRNA.
DR RefSeq; NP_001038478.2; NM_001045013.2.
DR AlphaFoldDB; A0JMK9; -.
DR STRING; 7955.ENSDARP00000101598; -.
DR iPTMnet; A0JMK9; -.
DR PaxDb; A0JMK9; -.
DR PeptideAtlas; A0JMK9; -.
DR PRIDE; A0JMK9; -.
DR Ensembl; ENSDART00000111711; ENSDARP00000101598; ENSDARG00000062152.
DR GeneID; 563212; -.
DR KEGG; dre:563212; -.
DR CTD; 10036; -.
DR ZFIN; ZDB-GENE-030131-5366; chaf1a.
DR eggNOG; KOG4364; Eukaryota.
DR GeneTree; ENSGT00440000034888; -.
DR InParanoid; A0JMK9; -.
DR OMA; CKWTYLT; -.
DR OrthoDB; 1362011at2759; -.
DR PhylomeDB; A0JMK9; -.
DR TreeFam; TF350377; -.
DR PRO; PR:A0JMK9; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 22.
DR Bgee; ENSDARG00000062152; Expressed in blastula and 22 other tissues.
DR ExpressionAtlas; A0JMK9; baseline.
DR GO; GO:0033186; C:CAF-1 complex; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0031497; P:chromatin assembly; ISS:UniProtKB.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0006334; P:nucleosome assembly; IBA:GO_Central.
DR InterPro; IPR029105; CAF1-p150_C2.
DR InterPro; IPR029091; CAF1_p150_N.
DR InterPro; IPR022043; CAF1A.
DR Pfam; PF15539; CAF1-p150_C2; 1.
DR Pfam; PF15557; CAF1-p150_N; 1.
DR Pfam; PF12253; CAF1A; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Chaperone; DNA damage; DNA repair; DNA replication; Nucleus;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..863
FT /note="Chromatin assembly factor 1 subunit A"
FT /id="PRO_0000373883"
FT REGION 1..353
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 423..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 513..579
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 749..863
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..55
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 112..126
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..153
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..196
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..243
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 248..353
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 513..547
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 749..785
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 802..817
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 820..847
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 111
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18307296"
FT MOD_RES 118
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18307296"
FT CONFLICT 146..210
FT /note="Missing (in Ref. 1; CAK04065)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 863 AA; 97223 MW; 61C1251E909E9E9F CRC64;
MVVVMLAAEE PLASTPRRDM DCVGKANTNK KLVQARLPFK RLNPEPKECN EPKRTKGPVA
PKCSEPSDQE NDQDSSSISH HGPALVNGRG PLDCFMSRRK RSPLRSAPEA TIDLTEDSND
SAKQQPAPPI AATCPLSEEK TKTSEGTTEP TIPLTEEETE KDEAEDVDAL PLLDITQDSD
TEEEEEEEEE EEEQQQEAEV SHGNESVLST GSTSSASVIA SSPEPSKSAP TTPASTSRIN
AANKVKRRSL KSVQEQEEKQ RQRDEKERLK QEAKAAKEKK KEEARKMKEE KEREKKEKKE
KDEKERREKK ERDEKEKADK LKAKEEQRQM KIEAKLEEKR KKEEEKRLKE EKDRIKAEKA
EITRFLQKPK TQLAPKTLAS ACGKFAPFEI KAHMSLAPLT RVQCEDSVLE DLDRYLAQPD
STLNGLKDWT GHKPRSSGPT RPRHSAQGDC VVITESQKAD DGPDRSRYGR MKLLHFHDNY
RPAYWGTWSK KSTHISPRCP LRLDKDLLDY EVDSDEEWEE EEPGESLSHS EGDDDDEAGE
DDDDDDGFFV PHGYLSEGEG ALEDEEGGDP EKQKVRQRMK AREWENELMS KGKVKVLEAV
VRGCFWEGEK PLPDFLQPYA VCMLEPLSKD EASTPEQDAS RQQRNEKLLT MLLPLLHGNV
NSNKVIITEF LEFCRQQTSS PTESLLNTTE SIPPRIHVRR IIKENAVYEK RSTFKRCCWY
VHADVLARYS QEALPVPCQW SYLTSGANVT RDEHSGSQGN SPTTNSSTTP SNKRKSASSH
SITKYMKKCG ESEQTEAMET DGFQADTEDD EDDDCIIIGE QSGSSEQDIN TSLPQTDRET
EPMDTSASET AALALPCPTP ATA
