ID   UVRC_CLOD6              Reviewed;         605 AA.
AC   Q180Q8;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=CD630_34100;
OS   Clostridioides difficile (strain 630) (Peptoclostridium difficile).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Peptostreptococcaceae;
OC   Clostridioides.
OX   NCBI_TaxID=272563;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=630;
RX   PubMed=16804543; DOI=10.1038/ng1830;
RA   Sebaihia M., Wren B.W., Mullany P., Fairweather N.F., Minton N.,
RA   Stabler R., Thomson N.R., Roberts A.P., Cerdeno-Tarraga A.M., Wang H.,
RA   Holden M.T.G., Wright A., Churcher C., Quail M.A., Baker S., Bason N.,
RA   Brooks K., Chillingworth T., Cronin A., Davis P., Dowd L., Fraser A.,
RA   Feltwell T., Hance Z., Holroyd S., Jagels K., Moule S., Mungall K.,
RA   Price C., Rabbinowitsch E., Sharp S., Simmonds M., Stevens K., Unwin L.,
RA   Whithead S., Dupuy B., Dougan G., Barrell B., Parkhill J.;
RT   "The multidrug-resistant human pathogen Clostridium difficile has a highly
RT   mobile, mosaic genome.";
RL   Nat. Genet. 38:779-786(2006).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; AM180355; CAJ70313.1; -; Genomic_DNA.
DR   RefSeq; WP_003436264.1; NZ_CP010905.2.
DR   RefSeq; YP_001089930.1; NC_009089.1.
DR   AlphaFoldDB; Q180Q8; -.
DR   SMR; Q180Q8; -.
DR   STRING; 272563.CD630_34100; -.
DR   PRIDE; Q180Q8; -.
DR   EnsemblBacteria; CAJ70313; CAJ70313; CD630_34100.
DR   GeneID; 66355867; -.
DR   KEGG; cdf:CD630_34100; -.
DR   KEGG; pdc:CDIF630_03715; -.
DR   PATRIC; fig|272563.120.peg.3604; -.
DR   eggNOG; COG0322; Bacteria.
DR   OMA; HIECFDN; -.
DR   PhylomeDB; Q180Q8; -.
DR   BioCyc; PDIF272563:G12WB-3584-MON; -.
DR   Proteomes; UP000001978; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR041663; DisA/LigA_HHH.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF12826; HHH_2; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..605
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000264884"
FT   DOMAIN          13..92
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          205..240
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   605 AA;  70356 MW;  F64DD341F6EB7924 CRC64;
     MFDIQEHLKK LPSEPGVYLM KDKYDHIIYV GKAISLKNRV RQYFQSSKNH TSKVKSMVKN
     IYKFEYIITD SELEALILEC NLIKRYRPKY NVVLRDDKTY PYIKVTTNED YPRILKVRRV
     LKDKAKYFGP YTNITAVNDT LELISSTYPI RSCKIDIDKA IKNKTRPCLN LHINKCLGPC
     TGNVSKEEYG KMIEEIIMCL SGKEEKLMEL LKEKMNESSM NFRFEEAAVY RDKIKSLEEM
     IQKQKIDATV SDLNQDVVAM ARAHNEACVQ VFFIRNGKIV GREHFILEGV MDSPRASILS
     SFVKQFYNEQ EYIPKELIIE DEIEDSSILE EWLSSKKGQK VTIRVPQKGE KKSLVEMVRK
     NAVEYLEKFS DMNKRKYEKS IGALEELKQI LNLEKLPIRI EAYDISNIQG VDSIGSMVVY
     TNAKKDKKEY RRYKIKTVIG PNDYDSMAEI VDRRLKHGNL PDLILLDGGK GQVSAVKKVL
     ELNDVDIPLW GMYKDDKHRT KGLICKEKEI ELDKTTNLYR FIASIQEEVH NYAITYHRSL
     RNKALTKSIL DDIQGIGEKR KKSLLNHFKD VDAIKKATME ELLEVDGMNK SIADNVYNFF
     RKEEN