ID   UVRC_COREF              Reviewed;         681 AA.
AC   Q8FT60;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=CE1711;
OS   Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189
OS   / NBRC 100395).
OC   Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC   Corynebacterium.
OX   NCBI_TaxID=196164;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395;
RX   PubMed=12840036; DOI=10.1101/gr.1285603;
RA   Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S.,
RA   Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T.;
RT   "Comparative complete genome sequence analysis of the amino acid
RT   replacements responsible for the thermostability of Corynebacterium
RT   efficiens.";
RL   Genome Res. 13:1572-1579(2003).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; BA000035; BAC18521.1; -; Genomic_DNA.
DR   RefSeq; WP_006767712.1; NZ_GG700683.1.
DR   AlphaFoldDB; Q8FT60; -.
DR   SMR; Q8FT60; -.
DR   STRING; 196164.23493551; -.
DR   PRIDE; Q8FT60; -.
DR   EnsemblBacteria; BAC18521; BAC18521; BAC18521.
DR   KEGG; cef:CE1711; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_2_11; -.
DR   OMA; HIECFDN; -.
DR   OrthoDB; 1036075at2; -.
DR   Proteomes; UP000001409; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..681
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000227418"
FT   DOMAIN          16..95
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          208..243
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   681 AA;  77174 MW;  4A83404EBB7BCF68 CRC64;
     MADPTTYRPA PGTIPTEPGV YKFRDDARRV IYVGKAKNLR ARLSNYFQDV TQLHPRTRQM
     VFAASSVEWT VVGSEVEALQ LEYTWIKRFD PRFNVKYRDD KSYPMLAVST GERFPRAFFY
     RGPRRKGVRY YGPYSHAWAV RETLDLLIRV FPMRTCSKGV FNRHENLGRP CLLGYIDKCA
     APCVGRVSEE EHREIVEGFC SFMSGHTDKV TRELTAEMMA ASEELDFERA ARLRDDLGAI
     NKVMEKQAVV LGDGTDADII AFATDELEAA VQIFHVRGGR IRGQRGWVVE KTGDWDLPDD
     SDAEGPDPAL PHLMQHFLVQ FYGDAVERAE SEAAEDAEHI ERRGVDQYRE ATPAVVPREI
     LVQVEPHEAQ ETRKVLEELR GAGVDLRVPQ RGDKRSLMET VEKNAREQLK QHKIKRVGDL
     TARSAALQDI QEALDMEQAP LRIECTDISH IQGTDVVASL VVFEDGLPRK SDYRRYRIKE
     AAGDGHSNDV ASIAEVTRRR FLRHHRDKLA VPEELDDATF SDEKVEEMST DNRRFAYPPQ
     LFIVDGGAPQ VAAAQEVFDE LGIVDVTLVG LAKRLEEIWL PGDPDPVILP RNSPALFLLQ
     QVRDEAHRFA ITYHRQQRSK RMRVSELDDI RGLGQARRTE LVKHFGSVAR LREATVGDIA
     GVRGFGPKLA QSVFEALHPP E