ID   UVRC_CORGB              Reviewed;         696 AA.
AC   A4QEG6;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=cgR_1640;
OS   Corynebacterium glutamicum (strain R).
OC   Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC   Corynebacterium.
OX   NCBI_TaxID=340322;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=R;
RX   PubMed=17379713; DOI=10.1099/mic.0.2006/003657-0;
RA   Yukawa H., Omumasaba C.A., Nonaka H., Kos P., Okai N., Suzuki N., Suda M.,
RA   Tsuge Y., Watanabe J., Ikeda Y., Vertes A.A., Inui M.;
RT   "Comparative analysis of the Corynebacterium glutamicum group and complete
RT   genome sequence of strain R.";
RL   Microbiology 153:1042-1058(2007).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; AP009044; BAF54632.1; -; Genomic_DNA.
DR   RefSeq; WP_011897303.1; NC_009342.1.
DR   AlphaFoldDB; A4QEG6; -.
DR   SMR; A4QEG6; -.
DR   EnsemblBacteria; BAF54632; BAF54632; cgR_1640.
DR   KEGG; cgt:cgR_1640; -.
DR   HOGENOM; CLU_014841_3_2_11; -.
DR   OMA; HIECFDN; -.
DR   PhylomeDB; A4QEG6; -.
DR   Proteomes; UP000006698; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   SOS response.
FT   CHAIN           1..696
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_1000077776"
FT   DOMAIN          16..95
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          208..243
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   696 AA;  78334 MW;  E742491E15C38A8B CRC64;
     MADPTTYRPA PGTIPTEPGV YKFRDENRRV IYVGKAKNLR SRLSNYFQDV TQLHPRTRQM
     VFAASSVEWT VVSSEVEALQ LEYTWIKRFD PRFNVKYRDD KTYPMLAVST GERFPRAFFF
     RGPRRKGVRY FGPYSHAWAV RETLDLLTRV FPMRTCSKGV FNRHESLGRP CLLGYIDKCA
     APCVGRVSEE EHREIVDGFT SFMAGHTDKV TRKLNADMMA AAEELDFERA ARLRDDLEAI
     DKVMEKQAVV LGDGTDADII AFATDQLEAA VQVFNIRGGR IRGQRGWVVD KPGDYAGLLV
     DATTQPEGDA PETDPALPFL MQDFLVQFYG DAVERAETEA KEDAAVIERR GVDKHSFEEA
     APVTRASVVP REILVQVAPN EAEQTLKVLE ELRGAGVDAR VPQRGDKRAL METVERNAKE
     LLKQHKLKRV GDLTARSAAL QELQEALDME QAPLRIECTD ISHIQGTDVV ASLVVFEDGL
     PRKSDYRRYR VKEAAGDGHS NDVASIAEIT RRRFLRHNQD KLAVPEAEEF DGSTFSDEKV
     EEMSTDARRF AYPPQIFIVD GGAPQVAAAQ EVFDELGIVD VVLIGLAKRL EEIWLPGDPD
     PVILPRNSQA LFLLQQIRDE AHRFAITYHR QQRSKRMRVS ELDSIKGLGQ SRRTELVKHF
     GSVAKLKEAS VEDISQVKGF GPKLAEAVYE GLHASK