ID   UVRC_CORJK              Reviewed;         690 AA.
AC   Q4JVI8;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=jk1005;
OS   Corynebacterium jeikeium (strain K411).
OC   Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC   Corynebacterium.
OX   NCBI_TaxID=306537;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K411;
RX   PubMed=15968079; DOI=10.1128/jb.187.13.4671-4682.2005;
RA   Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A.,
RA   Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F.,
RA   Rupp O., Schneiker S., Viehoever P., Puehler A.;
RT   "Complete genome sequence and analysis of the multiresistant nosocomial
RT   pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the
RT   human skin flora.";
RL   J. Bacteriol. 187:4671-4682(2005).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CR931997; CAI37169.1; -; Genomic_DNA.
DR   RefSeq; WP_011273577.1; NC_007164.1.
DR   AlphaFoldDB; Q4JVI8; -.
DR   SMR; Q4JVI8; -.
DR   STRING; 306537.jk1005; -.
DR   EnsemblBacteria; CAI37169; CAI37169; jk1005.
DR   GeneID; 56649635; -.
DR   KEGG; cjk:jk1005; -.
DR   PATRIC; fig|306537.10.peg.1017; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_2_11; -.
DR   OMA; HIECFDN; -.
DR   OrthoDB; 1036075at2; -.
DR   Proteomes; UP000000545; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..690
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000227420"
FT   DOMAIN          15..94
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          207..242
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   690 AA;  77295 MW;  AA90ED9188FA2C25 CRC64;
     MTSVSYRPEP GSIPTDPGVY TFRDAHERVI YVGKAKNLRA RLSNYFQDLD QLHPRTRAMV
     QSANHVQWTV VSSELEALNL EYTWIKRFNP RFNVMYRDDK TYPMLAISVK EQIPRAFMYR
     GPRRKGVRYF GPYPKAWAIR ETLESLTRVF PIRTCSAGVY RRHEALGRPC LLGYIDRCSA
     PCVGKITPED HRALVDQFSS FLAGNTEPVL RRVRKEMEQA SENLDFERAA SLRDQLQAMQ
     KSMERQAVVF SDNTDADLIA FVADELEAAV QIFHVRGGRI HGQRGWVVER EDLSEEKLVA
     DFITQFYGET AELAKATETQ VGGASGPEVD RDLARAINPA AAQDLGDLVG DVQVTPVPRE
     ILVHAMPDDA DDLAAWLTSL RGSNMQIRVP QRGDKKALMT TAETNATQAL AQHKLKRAGD
     ITARSAALKE LQEALWMDES PLRIECTDIS HIQGTDVVAS LVVFEDGLPK KADYRRYKIR
     DAAGDGHSDD VASIAEVVRR RFKRYQQDKS AVPAGDDAGD LLEGETELED NSAEGTDPAT
     EKRKFAYPPQ LFIVDGGLPQ VNAAQEVLDE LGVNDVTLVG IAKRLEEIWV PGEEYPIIVP
     RNSPALYLVQ NLRDEAHRFA ITFHRQQRSA RMRRSKLDDI PGLGPKRRKQ LVKEFGSVAR
     VKEASVEDIA ALPGFGPKLA QLIHDALNAE