ID   UVRC_CUPMC              Reviewed;         673 AA.
AC   Q1LKN9;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=Rmet_2410;
OS   Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 /
OS   CH34) (Ralstonia metallidurans).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=266264;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43123 / DSM 2839 / NBRC 102507 / CH34;
RX   PubMed=20463976; DOI=10.1371/journal.pone.0010433;
RA   Janssen P.J., Van Houdt R., Moors H., Monsieurs P., Morin N., Michaux A.,
RA   Benotmane M.A., Leys N., Vallaeys T., Lapidus A., Monchy S., Medigue C.,
RA   Taghavi S., McCorkle S., Dunn J., van der Lelie D., Mergeay M.;
RT   "The complete genome sequence of Cupriavidus metallidurans strain CH34, a
RT   master survivalist in harsh and anthropogenic environments.";
RL   PLoS ONE 5:E10433-E10433(2010).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CP000352; ABF09287.1; -; Genomic_DNA.
DR   RefSeq; WP_011517006.1; NC_007973.1.
DR   AlphaFoldDB; Q1LKN9; -.
DR   SMR; Q1LKN9; -.
DR   STRING; 266264.Rmet_2410; -.
DR   PRIDE; Q1LKN9; -.
DR   EnsemblBacteria; ABF09287; ABF09287; Rmet_2410.
DR   KEGG; rme:Rmet_2410; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_0_4; -.
DR   OMA; HIECFDN; -.
DR   OrthoDB; 1036075at2; -.
DR   Proteomes; UP000002429; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..673
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000264929"
FT   DOMAIN          39..117
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          226..261
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   673 AA;  74070 MW;  F686AC12A2FE3466 CRC64;
     MPEQEPVPPT ETTSPESDTP ESSDAPAFDP RPILARMPGL PGVYRYFDAD GNILYVGKAR
     DLKKRVSSYF NKTQLSPRIA MMVAKIARID TTVVRTEAEA LLLENNLIKA LAPRYNILFR
     DDKSYPFLRL TGHKFPRMAY YRGATDRKHQ YFGPFPSAHA VRESMQILQK VFQLRTCEDT
     VFNNRTRPCL LHQIHRCTGP CVGAISEDDY ARDVSNAARF LQGRETEVLE GLQSKMEAHA
     VQLEFEQAAA VRDQIAALST VLKRQAVEEV GQARDIDILA VAVQGGRACV NLAMVRGGRH
     LGDKAYFPAH VDEAAMIVEE GDEADGSAHE GAAADTDQLP IDRIAARVLS AFMVQHYLDQ
     APPPIVVVSH RPADSALVEA LSMQAGRKIT LVRQPQGQRK TWLEMAAQGA GLALARRLAE
     QGSQEARTRA LAETIGLDLE DLATLRIECF DISHTAGEAT QASCVVFHHH EMQNSEYRRY
     NIADITPGDD YAAMRQVLTR RYQKLVEQLQ EAGGDPAGDG GDGVPRMPRV VLIDGGKGQV
     EVARQVFEEL GLDIGLLVGV AKGEGRKVGL ETLVFADGRP SLELGQGSAA LMLVAQIRDE
     AHRFAITGMR ARRAKARTTS RLEEIEGVGA RRRQKLLTRF GGLRGVMAAS IDELASVEGI
     SRTLAEEIYR QLH