ID   UVRC_CUTAK              Reviewed;         672 AA.
AC   Q6A9J8;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 2.
DT   25-MAY-2022, entry version 114.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=PPA0812;
OS   Cutibacterium acnes (strain DSM 16379 / KPA171202) (Propionibacterium
OS   acnes).
OC   Bacteria; Actinobacteria; Propionibacteriales; Propionibacteriaceae;
OC   Cutibacterium.
OX   NCBI_TaxID=267747;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 16379 / KPA171202;
RX   PubMed=15286373; DOI=10.1126/science.1100330;
RA   Brueggemann H., Henne A., Hoster F., Liesegang H., Wiezer A.,
RA   Strittmatter A., Hujer S., Duerre P., Gottschalk G.;
RT   "The complete genome sequence of Propionibacterium acnes, a commensal of
RT   human skin.";
RL   Science 305:671-673(2004).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAT82568.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE017283; AAT82568.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_002531001.1; NZ_CP025935.1.
DR   AlphaFoldDB; Q6A9J8; -.
DR   SMR; Q6A9J8; -.
DR   STRING; 267747.PPA0812; -.
DR   EnsemblBacteria; AAT82568; AAT82568; PPA0812.
DR   KEGG; pac:PPA0812; -.
DR   PATRIC; fig|267747.3.peg.848; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_1_1_11; -.
DR   OMA; HIECFDN; -.
DR   Proteomes; UP000000603; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   SOS response.
FT   CHAIN           1..672
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000227461"
FT   DOMAIN          16..95
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          208..243
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   672 AA;  74695 MW;  7571AD5018F475A5 CRC64;
     MADPSSYRPA PGTIPTQPGV YRFSDAHGQV IYVGKAKNLR NRLNSYFQDI SALHPRTQRM
     VTTAAHVQWT VVQNEVESLQ LEYTWIKEFD PRFNVMYRDD KSYPWLCFTW TDEYPRVFVG
     RGAHHKGWRY YGPFGQAWAI RDTVETLLRV FPMRSCSTGV FNRAKNQGRP CLLGYIGKCS
     APCVERITSE AHREIADEFC DFMAGRTTKI VKRLESQMAE ASENLEFERA AVIRDSLGAL
     SKTLERNAVV LGDGTDADVI SMALDPLEVG VKIFHVRGGR IRGERGWVAD RADDADEAEL
     METFLTQLYG VNASDGQVRD DGHGNAVPPL VLVSAEPTNP DVMSTILSSE RGSHVEIRVP
     RRGDKATLMD TVTRNAQETL AQHKLKRASD LATRTRALEE IQESLGLDRA PLRMESYDIS
     HIQGTNVVGS MVVFEDGMPR KSEYRRFSIK GFEGSDDFAA MHEVLSRRLR RLIEDRDAMA
     AAQTPDGDVG SLIDPTTGSP RKFAYAPHLI VVDGGAPQVH AAQQVLEEFG LEDEIALCGL
     AKRLEEVWLP DEEWPVILPR TSEGLYLLQR LRDEAHRFAI TFHRSKRSKA MVESVLDGVS
     GLGETRRKAL VSHFGSVRSL RKATVDDIVE VPGFGPKLAG EVVAALSQDK PAEAINTATG
     EVVDANGPDA GR