UVRC_DEHM1
ID UVRC_DEHM1 Reviewed; 607 AA.
AC Q3Z770;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 27-SEP-2005, sequence version 1.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=DET1216;
OS Dehalococcoides mccartyi (strain ATCC BAA-2266 / KCTC 15142 / 195)
OS (Dehalococcoides ethenogenes (strain 195)).
OC Bacteria; Chloroflexi; Dehalococcoidia; Dehalococcoidales;
OC Dehalococcoidaceae; Dehalococcoides.
OX NCBI_TaxID=243164;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-2266 / KCTC 15142 / 195;
RX PubMed=15637277; DOI=10.1126/science.1102226;
RA Seshadri R., Adrian L., Fouts D.E., Eisen J.A., Phillippy A.M., Methe B.A.,
RA Ward N.L., Nelson W.C., DeBoy R.T., Khouri H.M., Kolonay J.F., Dodson R.J.,
RA Daugherty S.C., Brinkac L.M., Sullivan S.A., Madupu R., Nelson K.E.,
RA Kang K.H., Impraim M., Tran K., Robinson J.M., Forberger H.A., Fraser C.M.,
RA Zinder S.H., Heidelberg J.F.;
RT "Genome sequence of the PCE-dechlorinating bacterium Dehalococcoides
RT ethenogenes.";
RL Science 307:105-108(2005).
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC lesion. The N-terminal half is responsible for the 3' incision and the
CC C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC Rule:MF_00203}.
CC -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC {ECO:0000255|HAMAP-Rule:MF_00203}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC Rule:MF_00203}.
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DR EMBL; CP000027; AAW39514.1; -; Genomic_DNA.
DR RefSeq; WP_010936906.1; NC_002936.3.
DR AlphaFoldDB; Q3Z770; -.
DR SMR; Q3Z770; -.
DR STRING; 243164.DET1216; -.
DR EnsemblBacteria; AAW39514; AAW39514; DET1216.
DR KEGG; det:DET1216; -.
DR PATRIC; fig|243164.10.peg.1149; -.
DR eggNOG; COG0322; Bacteria.
DR HOGENOM; CLU_014841_3_2_0; -.
DR OMA; HIECFDN; -.
DR OrthoDB; 1036075at2; -.
DR Proteomes; UP000008289; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.420.340; -; 1.
DR Gene3D; 3.40.1440.10; -; 1.
DR HAMAP; MF_00203; UvrC; 1.
DR InterPro; IPR041663; DisA/LigA_HHH.
DR InterPro; IPR000305; GIY-YIG_endonuc.
DR InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR001943; UVR_dom.
DR InterPro; IPR036876; UVR_dom_sf.
DR InterPro; IPR004791; UvrC.
DR InterPro; IPR001162; UvrC_RNase_H_dom.
DR InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR Pfam; PF01541; GIY-YIG; 1.
DR Pfam; PF12826; HHH_2; 1.
DR Pfam; PF02151; UVR; 1.
DR Pfam; PF08459; UvrC_HhH_N; 1.
DR SMART; SM00465; GIYc; 1.
DR SMART; SM00278; HhH1; 2.
DR SUPFAM; SSF46600; SSF46600; 1.
DR SUPFAM; SSF47781; SSF47781; 1.
DR SUPFAM; SSF82771; SSF82771; 1.
DR TIGRFAMs; TIGR00194; uvrC; 1.
DR PROSITE; PS50164; GIY_YIG; 1.
DR PROSITE; PS50151; UVR; 1.
DR PROSITE; PS50165; UVRC; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW Reference proteome; SOS response.
FT CHAIN 1..607
FT /note="UvrABC system protein C"
FT /id="PRO_0000227423"
FT DOMAIN 15..94
FT /note="GIY-YIG"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT DOMAIN 204..239
FT /note="UVR"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ SEQUENCE 607 AA; 68324 MW; 19DF5E4C20C4CD56 CRC64;
MPSETLQNQI ASLPENPGVY LMKNAQGEII YVGKAAVLKD RVKSYFVPPS RLEPKTRQLV
SQINELEYLI TGSEQEALIL ELNLIKRHRP YFNVRLKDDK GFPYLKITLN EKWPRIYITR
SMADDGGRYF GPFASTRSVR HTLQVLKELF RFRSCNRTEP EKRSRPCLEY DIHQCLSPCT
GKISKQDYDH LISQAILFLE GKQDKVLKLL AKLMNEASAR LDYETAALRR DQISSIKEVI
EGQQLAARVS GEQDAIAFAQ EGDLSMVQVF FIRRGKLIGR ESFSLQGTRE EKPGDILSEF
VKQFYHSSTQ IPPKIVTQYP LSDREILEKW LSERRGGKVQ ITAGLRGQPK DLINIVAENA
REQLKQARIK NLSSAATLTD ALEELQTALG LPLPPQRIEG YDISNIQGTN AVGSMVVFEN
GKPQKAHYRR FRIKTVKGAD DFSMLKEVIS RRFGRLNKDN AGESFARRPS LMLIDGGKGQ
LSSVKETLDT LGLEGQAVIG LAKEFEEIYL PGKSEPIRLM ANSPALQLLQ RVRDEAHRFA
LGYHLNIRHK SGLTSALDGI PGIGPSRRRL LIKTFGSVSG IRQASLDELL QVKGINQALA
LSIKELL