ID   UVRC_DESVH              Reviewed;         688 AA.
AC   Q72DX8;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 2.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=DVU_0801;
OS   Desulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / NCIMB 8303 / VKM
OS   B-1760 / Hildenborough).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfovibrionales;
OC   Desulfovibrionaceae; Desulfovibrio.
OX   NCBI_TaxID=882;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29579 / DSM 644 / NCIMB 8303 / VKM B-1760 / Hildenborough;
RX   PubMed=15077118; DOI=10.1038/nbt959;
RA   Heidelberg J.F., Seshadri R., Haveman S.A., Hemme C.L., Paulsen I.T.,
RA   Kolonay J.F., Eisen J.A., Ward N.L., Methe B.A., Brinkac L.M.,
RA   Daugherty S.C., DeBoy R.T., Dodson R.J., Durkin A.S., Madupu R.,
RA   Nelson W.C., Sullivan S.A., Fouts D.E., Haft D.H., Selengut J.,
RA   Peterson J.D., Davidsen T.M., Zafar N., Zhou L., Radune D., Dimitrov G.,
RA   Hance M., Tran K., Khouri H.M., Gill J., Utterback T.R., Feldblyum T.V.,
RA   Wall J.D., Voordouw G., Fraser C.M.;
RT   "The genome sequence of the anaerobic, sulfate-reducing bacterium
RT   Desulfovibrio vulgaris Hildenborough.";
RL   Nat. Biotechnol. 22:554-559(2004).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAS95281.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE017285; AAS95281.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_014524276.1; NC_002937.3.
DR   RefSeq; YP_010022.1; NC_002937.3.
DR   AlphaFoldDB; Q72DX8; -.
DR   SMR; Q72DX8; -.
DR   STRING; 882.DVU_0801; -.
DR   PaxDb; Q72DX8; -.
DR   EnsemblBacteria; AAS95281; AAS95281; DVU_0801.
DR   KEGG; dvu:DVU_0801; -.
DR   PATRIC; fig|882.5.peg.750; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_2_7; -.
DR   OMA; HIECFDN; -.
DR   PhylomeDB; Q72DX8; -.
DR   Proteomes; UP000002194; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..688
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000227428"
FT   DOMAIN          11..90
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          200..235
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   688 AA;  74433 MW;  BB763F7538F0F357 CRC64;
     MERPDLSTIP LTPGVYLYKD ESGRIIYVGK ARCLRRRVAS YFRDVSALTP KTVAMLRHAV
     TIDTLSTTTE KEALLLEASL IKKHRPRYNI VLRDDKQYVL FRIGAKHPYP RLEIVRKARR
     DDGRYFGPFT SASAARETWK TIHRAFPLRR CSDRAFGNRV RACLYHHMGQ CLGPCVNEVP
     SETYAALLEQ VSLLLSGRSG ELVDALRTEM EAASQGLDFE RAAVLRDRIR ALERTVERQA
     AVLPGGGDLD VVGVVEVENG LALGVLFVRQ GVLLDGRSFF WPGLGFAEAP ELLWSFLGQF
     YGPQATIPPR IVVPWLPDED GETGDALDGS SDAVVPVAAA TTIDASLADV RTGTEVTSLI
     NASHAAPNVG ESTQGDTLAG ATGKGATHLM LETALAALRG GIVRIALPRN PAENRLVDMA
     MSNAREEARR KADTPLQDLL ARALHLAGPP HRIEAVDVSH TGGRNTRVGM VVFEDGKPFP
     EAYRTYAFED GDGDDYGTLA AWAGRRVESG PPWPDLLLVD GGRGQLAAVV RAFEECGMGA
     AFAVASIAKA RTEEGRADRR AGNVSDRIFL PGRANPLPLR AGAPELLFLQ HVRDTVHDYS
     IGKHRRARAG AALTGELQRV EGIGPATARA LWERFDSLQA MADAGVEGLA AVPGVGRARA
     AALHAHLVTF FGSSKQGGHA RTALQRKG