ID   UVRC_ECO57              Reviewed;         610 AA.
AC   P0A8G2; P07028; P76311; Q8XBD5;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=UvrABC system protein C;
DE            Short=Protein UvrC;
DE   AltName: Full=Excinuclease ABC subunit C;
GN   Name=uvrC; OrderedLocusNames=Z3001, ECs2651;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAG56928.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAB36074.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE005174; AAG56928.1; ALT_INIT; Genomic_DNA.
DR   EMBL; BA000007; BAB36074.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_310678.2; NC_002695.1.
DR   RefSeq; WP_001283421.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; P0A8G2; -.
DR   SMR; P0A8G2; -.
DR   STRING; 155864.EDL933_2918; -.
DR   EnsemblBacteria; AAG56928; AAG56928; Z3001.
DR   EnsemblBacteria; BAB36074; BAB36074; ECs_2651.
DR   GeneID; 66674198; -.
DR   GeneID; 913874; -.
DR   KEGG; ece:Z3001; -.
DR   KEGG; ecs:ECs_2651; -.
DR   PATRIC; fig|386585.9.peg.2776; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_2_6; -.
DR   OMA; HIECFDN; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..610
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000138301"
FT   DOMAIN          16..94
FT                   /note="GIY-YIG"
FT   DOMAIN          204..239
FT                   /note="UVR"
SQ   SEQUENCE   610 AA;  68188 MW;  F76766477C9ABCB6 CRC64;
     MSDQFDAKAF LKTVTSQPGV YRMYDAGGTV IYVGKAKDLK KRLSSYFRSN LASRKTEALV
     AQIQQIDVTV THTETEALLL EHNYIKLYQP RYNVLLRDDK SYPFIFLSGD THPRLAMHRG
     AKHAKGEYFG PFPNGYAVRE TLALLQKIFP IRQCENSVYR NRSRPCLQYQ IGRCLGPCVE
     GLVSEEEYAQ QVEYVRLFLS GKDDQVLTQL ISRMETASQN LEFEEAARIR DQIQAVRRVT
     EKQFVSNTGD DLDVIGVAFD AGMACVHVLF IRQGKVLGSR SYFPKVPGGT ELSEVVETFV
     GQFYLQGSQM RTLPGEILLD FNLSDKTLLA DSLSELAGRK INVQTKPRGD RARYLKLART
     NAATALTSKL SQQSTVHQRL TALASVLKLP EVKRMECFDI SHTMGEQTVA SCVVFDANGP
     LRAEYRRYNI TGITPGDDYA AMNQVLRRRY GKAIDDSKIP DVILIDGGKG QLAQAKNVFA
     ELDVSWDKNH PLLLGVAKGA DRKAGLETLF FEPEGEGFSL PPDSPALHVI QHIRDESHDH
     AIGGHRKKRA KVKNTSSLET IEGVGPKRRQ MLLKYMGGLQ GLRNASVEEI AKVPGISQGL
     AEKIFWSLKH