CAF1B_CHICK
ID CAF1B_CHICK Reviewed; 566 AA.
AC Q5R1S9; Q5ZLM9;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Chromatin assembly factor 1 subunit B;
DE Short=CAF-1 subunit B;
DE AltName: Full=Chromatin assembly factor I p60 subunit;
DE Short=CAF-I 60 kDa subunit;
DE Short=CAF-I p60;
GN Name=CHAF1B; Synonyms=CAF1P60; ORFNames=RCJMB04_5h12;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND INTERACTION WITH CHAF1A.
RC TISSUE=B-cell;
RX PubMed=17065558; DOI=10.1091/mbc.e06-05-0426;
RA Takami Y., Ono T., Fukagawa T., Shibahara K., Nakayama T.;
RT "Essential role of chromatin assembly factor-1-mediated rapid nucleosome
RT assembly for DNA replication and cell division in vertebrate cells.";
RL Mol. Biol. Cell 18:129-141(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Complex that is thought to mediate chromatin assembly in DNA
CC replication and DNA repair. Assembles histone octamers onto replicating
CC DNA in vitro. CAF-1 performs the first step of the nucleosome assembly
CC process, bringing newly synthesized histones H3 and H4 to replicating
CC DNA; histones H2A/H2B can bind to this chromatin precursor subsequent
CC to DNA replication to complete the histone octamer.
CC {ECO:0000269|PubMed:17065558}.
CC -!- SUBUNIT: Interacts with CHAF1A. {ECO:0000269|PubMed:17065558}.
CC -!- INTERACTION:
CC Q5R1S9; Q3C1E9: ASF1; NbExp=2; IntAct=EBI-996875, EBI-996834;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q13112}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB195693; BAD72953.1; -; mRNA.
DR EMBL; AJ719705; CAG31364.1; -; mRNA.
DR RefSeq; NP_001008677.2; NM_001008677.2.
DR AlphaFoldDB; Q5R1S9; -.
DR SMR; Q5R1S9; -.
DR BioGRID; 679736; 1.
DR IntAct; Q5R1S9; 1.
DR STRING; 9031.ENSGALP00000025797; -.
DR PaxDb; Q5R1S9; -.
DR GeneID; 418514; -.
DR KEGG; gga:418514; -.
DR CTD; 8208; -.
DR VEuPathDB; HostDB:geneid_418514; -.
DR eggNOG; KOG1009; Eukaryota.
DR InParanoid; Q5R1S9; -.
DR OrthoDB; 685536at2759; -.
DR PhylomeDB; Q5R1S9; -.
DR PRO; PR:Q5R1S9; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0033186; C:CAF-1 complex; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0031497; P:chromatin assembly; ISS:UniProtKB.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0006335; P:DNA replication-dependent chromatin assembly; IEA:InterPro.
DR GO; GO:0006334; P:nucleosome assembly; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR029129; CAF1_p60_C.
DR InterPro; IPR001632; Gprotein_B.
DR InterPro; IPR045145; PTHR15271.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR15271; PTHR15271; 1.
DR Pfam; PF15512; CAF-1_p60_C; 1.
DR Pfam; PF00400; WD40; 3.
DR PRINTS; PR00319; GPROTEINB.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Cell cycle; DNA damage; DNA repair; DNA replication; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation;
KW WD repeat.
FT CHAIN 1..566
FT /note="Chromatin assembly factor 1 subunit B"
FT /id="PRO_0000373880"
FT REPEAT 11..54
FT /note="WD 1"
FT REPEAT 64..103
FT /note="WD 2"
FT REPEAT 127..166
FT /note="WD 3"
FT REPEAT 169..208
FT /note="WD 4"
FT REPEAT 228..279
FT /note="WD 5"
FT REPEAT 351..392
FT /note="WD 6"
FT REGION 411..481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 501..566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 415..438
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 454..481
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 434
FT /note="T -> A (in Ref. 2; CAG31364)"
FT /evidence="ECO:0000305"
FT CONFLICT 520
FT /note="P -> H (in Ref. 2; CAG31364)"
FT /evidence="ECO:0000305"
FT CONFLICT 533
FT /note="G -> D (in Ref. 2; CAG31364)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 566 AA; 62578 MW; 53A17D98B3A828A8 CRC64;
MKVITCEIAW HNKEPVYSLD FQHGTDGKIN RLASAGVDTA VRVWKVEKGP DGKAIVEFLS
NLARHTKAVN VVRFSPSGEV LASGGDDAVI LLWKLNDSKE LEPLAFQDED EAQLNKENWT
VVKTLRGHLE DVYDICWTSD GNYMASASVD NTAIMWDVVK GQKVSILNEH KSYVQGITWD
PLGQYIATLS CDRVLRVYNT QTKRVAFNVT KMPSESGAEG EARSYRMFHD DSMKSFFRRL
SFTPDGSLLL TPAGCVESGE NVTNTTYVFS RNNLKRPMGH LPCPGKATLA VRCCPVYFEL
RQALNKGEVS QKSSPALLNL PYRLVFAVAS EDSVLFYDTE QSFPFGYVSN IHYHTLSDIS
WSSDGAFLAI SSTDGYCSFV TFEKDELGIP LKEKPQIHVR TSVVTEKKVK KSQPNKVISP
GSRLTEGTSL STPTLQPKTP VAAAKDLPST PVGIKNVPVS SSEERKISQP ASQSTKVNQP
RRITLNTLQA WSKTPRRVNL IPLKPDTPAS VYTDTVPVPP SSEQEHERPL PSGDSLQNPP
ASKRPRTEEM PLSVSAEDQI GCKPNK
