UVRC_ENTFA
ID UVRC_ENTFA Reviewed; 598 AA.
AC Q835H1;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=EF_1406;
OS Enterococcus faecalis (strain ATCC 700802 / V583).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=226185;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700802 / V583;
RX PubMed=12663927; DOI=10.1126/science.1080613;
RA Paulsen I.T., Banerjei L., Myers G.S.A., Nelson K.E., Seshadri R.,
RA Read T.D., Fouts D.E., Eisen J.A., Gill S.R., Heidelberg J.F., Tettelin H.,
RA Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C.,
RA DeBoy R.T., Durkin S.A., Kolonay J.F., Madupu R., Nelson W.C.,
RA Vamathevan J.J., Tran B., Upton J., Hansen T., Shetty J., Khouri H.M.,
RA Utterback T.R., Radune D., Ketchum K.A., Dougherty B.A., Fraser C.M.;
RT "Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus
RT faecalis.";
RL Science 299:2071-2074(2003).
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC lesion. The N-terminal half is responsible for the 3' incision and the
CC C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC Rule:MF_00203}.
CC -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC {ECO:0000255|HAMAP-Rule:MF_00203}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC Rule:MF_00203}.
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DR EMBL; AE016830; AAO81197.1; -; Genomic_DNA.
DR RefSeq; NP_815127.1; NC_004668.1.
DR RefSeq; WP_002357701.1; NZ_KE136528.1.
DR AlphaFoldDB; Q835H1; -.
DR SMR; Q835H1; -.
DR STRING; 226185.EF_1406; -.
DR PRIDE; Q835H1; -.
DR EnsemblBacteria; AAO81197; AAO81197; EF_1406.
DR KEGG; efa:EF1406; -.
DR PATRIC; fig|226185.45.peg.2095; -.
DR eggNOG; COG0322; Bacteria.
DR HOGENOM; CLU_014841_3_2_9; -.
DR OMA; HIECFDN; -.
DR Proteomes; UP000001415; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.420.340; -; 1.
DR Gene3D; 3.40.1440.10; -; 1.
DR HAMAP; MF_00203; UvrC; 1.
DR InterPro; IPR000305; GIY-YIG_endonuc.
DR InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR001943; UVR_dom.
DR InterPro; IPR036876; UVR_dom_sf.
DR InterPro; IPR004791; UvrC.
DR InterPro; IPR001162; UvrC_RNase_H_dom.
DR InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR Pfam; PF01541; GIY-YIG; 1.
DR Pfam; PF02151; UVR; 1.
DR Pfam; PF08459; UvrC_HhH_N; 1.
DR SMART; SM00465; GIYc; 1.
DR SUPFAM; SSF46600; SSF46600; 1.
DR SUPFAM; SSF47781; SSF47781; 1.
DR SUPFAM; SSF82771; SSF82771; 1.
DR TIGRFAMs; TIGR00194; uvrC; 1.
DR PROSITE; PS50164; GIY_YIG; 1.
DR PROSITE; PS50151; UVR; 1.
DR PROSITE; PS50165; UVRC; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW Reference proteome; SOS response.
FT CHAIN 1..598
FT /note="UvrABC system protein C"
FT /id="PRO_0000227429"
FT DOMAIN 14..91
FT /note="GIY-YIG"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT DOMAIN 196..231
FT /note="UVR"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ SEQUENCE 598 AA; 68643 MW; E82194189BE689A3 CRC64;
MNERIKNKLA LLPDQPGCYL MKDKNGTIIY VGKAKILKNR VRSYFRGSHD TKTERLVSEI
DDFEYIVTES NIEALLLEIN LIHKNNPKYN IMLKDDKTYP FIKITNEKYP RLMITRKVLK
DKALYFGPYP DVNAANETKK LLDRLFPLRK CNPSQKTPCL YYHLGQCLCP YAFDVDPQVY
KDMVEEIKGF LSGGHTEIQD RLQEKMAYAA AHMEFEKAAE FRDQIKAIET VMTRQKMTNV
DLIDRDVFGY AVDKGWMCVQ VFFVRQGKLI ERDVSIFPFY DDASEAFLTF IGQFYQENEH
FVPKEVLIPD DIDKESVEAL LATKVLQPQR GEKKKLVKLA SKNAAVALNE KFDLIVRKQE
RTIGAVEKLG NAMNIPAPIR IEAFDNSNIM GTNPVSAMVV FIDGRPAKNE YRKYKIKTVQ
GPDDYASMRE VIYRRYSRVL KEGLPFPDLI LIDGGKGQVD VAKDVLANQL GVDIPVAGLA
KNDKHKTSEL LFGPNLEVVP LERNSQEFFL LQRIQDEVHR FAITFHRQLR SKNSFASKLD
NIEGLGPKRK KNLLKEFKSL KNITAASVEE LRKAGLPETV AKNVYRHLHQ ETTSEIEK