ID   UVRC_FLAPJ              Reviewed;         599 AA.
AC   A6GW65;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=FP0222;
OS   Flavobacterium psychrophilum (strain ATCC 49511 / DSM 21280 / CIP 103535 /
OS   JIP02/86).
OC   Bacteria; Bacteroidetes; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Flavobacterium.
OX   NCBI_TaxID=402612;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49511 / DSM 21280 / CIP 103535 / JIP02/86;
RX   PubMed=17592475; DOI=10.1038/nbt1313;
RA   Duchaud E., Boussaha M., Loux V., Bernardet J.-F., Michel C., Kerouault B.,
RA   Mondot S., Nicolas P., Bossy R., Caron C., Bessieres P., Gibrat J.-F.,
RA   Claverol S., Dumetz F., Le Henaff M., Benmansour A.;
RT   "Complete genome sequence of the fish pathogen Flavobacterium
RT   psychrophilum.";
RL   Nat. Biotechnol. 25:763-769(2007).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; AM398681; CAL42338.1; -; Genomic_DNA.
DR   RefSeq; WP_011962398.1; NC_009613.3.
DR   RefSeq; YP_001295158.1; NC_009613.3.
DR   AlphaFoldDB; A6GW65; -.
DR   SMR; A6GW65; -.
DR   STRING; 402612.FP0222; -.
DR   PRIDE; A6GW65; -.
DR   EnsemblBacteria; CAL42338; CAL42338; FP0222.
DR   GeneID; 66553850; -.
DR   KEGG; fps:FP0222; -.
DR   PATRIC; fig|402612.5.peg.231; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_2_10; -.
DR   OMA; HIECFDN; -.
DR   Proteomes; UP000006394; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..599
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_1000077786"
FT   DOMAIN          15..93
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          207..242
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   599 AA;  69118 MW;  6C486AA26CB326B3 CRC64;
     MSISSLELQI QTLPDNPGVY QYYDKDGKIL YVGKAKNLKK RVSSYFNKVH DTAKTNVLVK
     KIVTIKHIVV PTETDALLLE NNLIKTLQPR YNILLRDDKT YPWICIKKEP FSRLFPTRKM
     VKDGSEYFGP YTSFKTVSVI LDLIKELYPL RSCNFDLSQK NIENYKFKVC LEYHIGNCKG
     ACEGLETLEN YQTQINAIRE ILKGNFKDSM KDFKKVMTNL AQNMHFEEAQ KIKEKIEILE
     NYQSRSTIIN PKITNIDVFS IVSDEAAAFI NFLQISHGSI IRSHTLEIKK KLDETDQELL
     ELAIVELRER FQLLSREIIV PFEVEVGENI KVTVPQLGDK KQILELSVRN AKFYRIEQLK
     QLQIVDPERH VNRIMAQMKK DLRLSVEPRH IECFDNSNIQ GTNPVAACVV FKDGKPSKKD
     YRHFNIKTVE GPNDFASMEE VVYRRYKRLL DENQPLPNLI IIDGGKGQLS SALKIIDELD
     LRGKIAIIGI AKRLEELFYP GDSIPLYLDK KSETLKIIQQ LRNEAHRFGI TFHRDKRSKA
     ALNSSIETIP GIGEKTMLTL IKHFKSVKRL KLAKEKEISD LIGISKAKKI TDFYSKLDN