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UVRC_FRACC
ID   UVRC_FRACC              Reviewed;         705 AA.
AC   Q2JCI3;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203};
GN   OrderedLocusNames=Francci3_1633;
OS   Frankia casuarinae (strain DSM 45818 / CECT 9043 / CcI3).
OC   Bacteria; Actinobacteria; Frankiales; Frankiaceae; Frankia.
OX   NCBI_TaxID=106370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 45818 / CECT 9043 / CcI3;
RX   PubMed=17151343; DOI=10.1101/gr.5798407;
RA   Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N.,
RA   Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N., Couloux A.,
RA   Cournoyer B., Cruveiller S., Daubin V., Demange N., Francino M.P.,
RA   Goltsman E., Huang Y., Kopp O.R., Labarre L., Lapidus A., Lavire C.,
RA   Marechal J., Martinez M., Mastronunzio J.E., Mullin B.C., Niemann J.,
RA   Pujic P., Rawnsley T., Rouy Z., Schenowitz C., Sellstedt A., Tavares F.,
RA   Tomkins J.P., Vallenet D., Valverde C., Wall L.G., Wang Y., Medigue C.,
RA   Benson D.R.;
RT   "Genome characteristics of facultatively symbiotic Frankia sp. strains
RT   reflect host range and host plant biogeography.";
RL   Genome Res. 17:7-15(2007).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CP000249; ABD11009.1; -; Genomic_DNA.
DR   RefSeq; WP_011436072.1; NZ_LRTJ01000018.1.
DR   AlphaFoldDB; Q2JCI3; -.
DR   SMR; Q2JCI3; -.
DR   STRING; 106370.Francci3_1633; -.
DR   EnsemblBacteria; ABD11009; ABD11009; Francci3_1633.
DR   KEGG; fra:Francci3_1633; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_2_0_11; -.
DR   OMA; HIECFDN; -.
DR   OrthoDB; 1036075at2; -.
DR   PhylomeDB; Q2JCI3; -.
DR   Proteomes; UP000001937; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..705
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000264895"
FT   DOMAIN          16..95
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          208..243
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   REGION          315..335
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          683..705
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        315..334
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   705 AA;  76943 MW;  C72756E0186CE485 CRC64;
     MADPASYRPA PGSIPETPGV YRFRDEHGRV LYVGKAKNLR ARLANYFAEL HTLHPRTQHM
     VSSASSVDWT VVSTEVEALQ LEYTWIKQFD PRFNVRYRDD KSYPSLAVTL HEEFPRLQVM
     RGPKRKGVRY FGPYAHAWAI RETLDLLLRV FPARTCSGGV FKRAAQVGRP CLLGYIDRCS
     APCVGRVDAA THREIVEDFC DFMSGQTGRY LRRLEREMQQ AAQAQEYERA ARLRDDIGAL
     RRAVEKQAVV LPDGTDADVI AFAEDELEAA VAVFYVRGGR VRGQRGWVVD KLDEVTTADL
     VEQFLTQEYL DGTGAASTGT AGSTVPTTTA GSQGEGIPRE ILVPALPPDV EAVTELLGAA
     RGSRVEVRVP RRGDKRTLLE TVERNAKQAF ALHRTKRASD LTARSRALAE LQEALELPDA
     PLRIECFDVS NTQGTNVVAS MVVFEDGLPR KSEYRRFAIR GIAGREGAGR EGAGDDVASM
     YETIHRRFSR YLAERSRIAD IADIAELGDI AGAPGAAQPI DPGTGRPRRF AYPPNLVVVD
     GGAPQVAAAA RALDELGIDA GPGGVALCGL AKRLEEVWLP DTADPVILPR TSEALYLLQR
     VRDEAHRFAI AYHRQKRSTA MVASALDEVP GLGDTRRKAL LRHFGSVAKI RAASAEQIAQ
     VSGIGPRTAA AIVTALARSA PGRADAPAPV VDPRTGEILD TETVS
 
 
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