UVRC_FRACC
ID UVRC_FRACC Reviewed; 705 AA.
AC Q2JCI3;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203};
GN OrderedLocusNames=Francci3_1633;
OS Frankia casuarinae (strain DSM 45818 / CECT 9043 / CcI3).
OC Bacteria; Actinobacteria; Frankiales; Frankiaceae; Frankia.
OX NCBI_TaxID=106370;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45818 / CECT 9043 / CcI3;
RX PubMed=17151343; DOI=10.1101/gr.5798407;
RA Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N.,
RA Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N., Couloux A.,
RA Cournoyer B., Cruveiller S., Daubin V., Demange N., Francino M.P.,
RA Goltsman E., Huang Y., Kopp O.R., Labarre L., Lapidus A., Lavire C.,
RA Marechal J., Martinez M., Mastronunzio J.E., Mullin B.C., Niemann J.,
RA Pujic P., Rawnsley T., Rouy Z., Schenowitz C., Sellstedt A., Tavares F.,
RA Tomkins J.P., Vallenet D., Valverde C., Wall L.G., Wang Y., Medigue C.,
RA Benson D.R.;
RT "Genome characteristics of facultatively symbiotic Frankia sp. strains
RT reflect host range and host plant biogeography.";
RL Genome Res. 17:7-15(2007).
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC lesion. The N-terminal half is responsible for the 3' incision and the
CC C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC Rule:MF_00203}.
CC -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC {ECO:0000255|HAMAP-Rule:MF_00203}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC Rule:MF_00203}.
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DR EMBL; CP000249; ABD11009.1; -; Genomic_DNA.
DR RefSeq; WP_011436072.1; NZ_LRTJ01000018.1.
DR AlphaFoldDB; Q2JCI3; -.
DR SMR; Q2JCI3; -.
DR STRING; 106370.Francci3_1633; -.
DR EnsemblBacteria; ABD11009; ABD11009; Francci3_1633.
DR KEGG; fra:Francci3_1633; -.
DR eggNOG; COG0322; Bacteria.
DR HOGENOM; CLU_014841_2_0_11; -.
DR OMA; HIECFDN; -.
DR OrthoDB; 1036075at2; -.
DR PhylomeDB; Q2JCI3; -.
DR Proteomes; UP000001937; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.420.340; -; 1.
DR Gene3D; 3.40.1440.10; -; 1.
DR HAMAP; MF_00203; UvrC; 1.
DR InterPro; IPR000305; GIY-YIG_endonuc.
DR InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR001943; UVR_dom.
DR InterPro; IPR036876; UVR_dom_sf.
DR InterPro; IPR004791; UvrC.
DR InterPro; IPR001162; UvrC_RNase_H_dom.
DR InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR Pfam; PF01541; GIY-YIG; 1.
DR Pfam; PF02151; UVR; 1.
DR Pfam; PF08459; UvrC_HhH_N; 1.
DR SMART; SM00465; GIYc; 1.
DR SMART; SM00278; HhH1; 2.
DR SUPFAM; SSF46600; SSF46600; 1.
DR SUPFAM; SSF47781; SSF47781; 1.
DR SUPFAM; SSF82771; SSF82771; 1.
DR TIGRFAMs; TIGR00194; uvrC; 1.
DR PROSITE; PS50164; GIY_YIG; 1.
DR PROSITE; PS50151; UVR; 1.
DR PROSITE; PS50165; UVRC; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW Reference proteome; SOS response.
FT CHAIN 1..705
FT /note="UvrABC system protein C"
FT /id="PRO_0000264895"
FT DOMAIN 16..95
FT /note="GIY-YIG"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT DOMAIN 208..243
FT /note="UVR"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT REGION 315..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 683..705
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 315..334
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 705 AA; 76943 MW; C72756E0186CE485 CRC64;
MADPASYRPA PGSIPETPGV YRFRDEHGRV LYVGKAKNLR ARLANYFAEL HTLHPRTQHM
VSSASSVDWT VVSTEVEALQ LEYTWIKQFD PRFNVRYRDD KSYPSLAVTL HEEFPRLQVM
RGPKRKGVRY FGPYAHAWAI RETLDLLLRV FPARTCSGGV FKRAAQVGRP CLLGYIDRCS
APCVGRVDAA THREIVEDFC DFMSGQTGRY LRRLEREMQQ AAQAQEYERA ARLRDDIGAL
RRAVEKQAVV LPDGTDADVI AFAEDELEAA VAVFYVRGGR VRGQRGWVVD KLDEVTTADL
VEQFLTQEYL DGTGAASTGT AGSTVPTTTA GSQGEGIPRE ILVPALPPDV EAVTELLGAA
RGSRVEVRVP RRGDKRTLLE TVERNAKQAF ALHRTKRASD LTARSRALAE LQEALELPDA
PLRIECFDVS NTQGTNVVAS MVVFEDGLPR KSEYRRFAIR GIAGREGAGR EGAGDDVASM
YETIHRRFSR YLAERSRIAD IADIAELGDI AGAPGAAQPI DPGTGRPRRF AYPPNLVVVD
GGAPQVAAAA RALDELGIDA GPGGVALCGL AKRLEEVWLP DTADPVILPR TSEALYLLQR
VRDEAHRFAI AYHRQKRSTA MVASALDEVP GLGDTRRKAL LRHFGSVAKI RAASAEQIAQ
VSGIGPRTAA AIVTALARSA PGRADAPAPV VDPRTGEILD TETVS