CAF1C_ARATH
ID CAF1C_ARATH Reviewed; 310 AA.
AC Q9SFX6;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Putative CCR4-associated factor 1 homolog 3;
DE EC=3.1.13.4;
GN Name=CAF1-3; OrderedLocusNames=At1g27820; ORFNames=F28L5.3, T22C5.28;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- FUNCTION: Ubiquitous transcription factor required for a diverse set of
CC processes. It is a component of the CCR4 complex involved in the
CC control of gene expression (By similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage of poly(A) to 5'-AMP.; EC=3.1.13.4;
CC -!- COFACTOR:
CC Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC Evidence={ECO:0000250};
CC -!- SUBUNIT: Component of the CCR4-NOT complex, at least composed of CRR4
CC and CAF1 proteins. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CAF1 family. {ECO:0000305}.
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DR EMBL; AC012375; AAF24955.1; -; Genomic_DNA.
DR EMBL; AC079280; AAG50574.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE30880.1; -; Genomic_DNA.
DR PIR; C86403; C86403.
DR RefSeq; NP_174103.1; NM_102547.1.
DR AlphaFoldDB; Q9SFX6; -.
DR SMR; Q9SFX6; -.
DR STRING; 3702.AT1G27820.1; -.
DR iPTMnet; Q9SFX6; -.
DR PaxDb; Q9SFX6; -.
DR PRIDE; Q9SFX6; -.
DR DNASU; 839676; -.
DR EnsemblPlants; AT1G27820.1; AT1G27820.1; AT1G27820.
DR GeneID; 839676; -.
DR Gramene; AT1G27820.1; AT1G27820.1; AT1G27820.
DR KEGG; ath:AT1G27820; -.
DR Araport; AT1G27820; -.
DR TAIR; locus:2029826; AT1G27820.
DR eggNOG; KOG0304; Eukaryota.
DR HOGENOM; CLU_027974_1_3_1; -.
DR InParanoid; Q9SFX6; -.
DR OMA; PVMFAAH; -.
DR OrthoDB; 931256at2759; -.
DR PhylomeDB; Q9SFX6; -.
DR PRO; PR:Q9SFX6; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9SFX6; baseline and differential.
DR Genevisible; Q9SFX6; AT.
DR GO; GO:0030015; C:CCR4-NOT core complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000932; C:P-body; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004535; F:poly(A)-specific ribonuclease activity; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0043928; P:exonucleolytic catabolism of deadenylated mRNA; IBA:GO_Central.
DR Gene3D; 3.30.420.10; -; 1.
DR InterPro; IPR039637; CNOT7/CNOT8/Pop2.
DR InterPro; IPR006941; RNase_CAF1.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR10797; PTHR10797; 1.
DR Pfam; PF04857; CAF1; 1.
DR SUPFAM; SSF53098; SSF53098; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Exonuclease; Hydrolase; Metal-binding; Nuclease; Nucleus;
KW Reference proteome; RNA-binding; Transcription; Transcription regulation.
FT CHAIN 1..310
FT /note="Putative CCR4-associated factor 1 homolog 3"
FT /id="PRO_0000371553"
FT BINDING 34
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000250"
FT BINDING 36
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000250"
FT BINDING 150
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000250"
FT BINDING 223
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000250"
SQ SEQUENCE 310 AA; 35923 MW; 4F27B3A9AECBDC8A CRC64;
MKQISSGEVW RWNKEVEMNS IRDCLKHCSS IAIDTEFPGC LKETPMDASE EIRYRDMKFN
VDNTHLIQLG FTLFDRRGFA KTWEINLSDF DEHKCFKNDK SIAFLKSNGL NLDKIREEGI
GIDEFFRDFS QILTEKDGKI TWVNFQGSYD NAYLVKGLTG GKPLPETKEE FHETVQQLLG
KFVFDVKKIA ESCSGLSSQF GLQRIADVLQ MKRVGKAHHA GSDSELTARV FTKLTFDLLN
SRKQSVRRVD HQQFQLEQQQ HQQFMMTRCY IPIPMPIPRP RPVMFAAHHQ NPYFGGGYFR
MPVQGMNYVL
