ID   UVRC_FRATT              Reviewed;         612 AA.
AC   Q5NGQ8;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=FTT_0777;
OS   Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Thiotrichales;
OC   Francisellaceae; Francisella.
OX   NCBI_TaxID=177416;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SCHU S4 / Schu 4;
RX   PubMed=15640799; DOI=10.1038/ng1499;
RA   Larsson P., Oyston P.C.F., Chain P., Chu M.C., Duffield M., Fuxelius H.-H.,
RA   Garcia E., Haelltorp G., Johansson D., Isherwood K.E., Karp P.D.,
RA   Larsson E., Liu Y., Michell S., Prior J., Prior R., Malfatti S.,
RA   Sjoestedt A., Svensson K., Thompson N., Vergez L., Wagg J.K., Wren B.W.,
RA   Lindler L.E., Andersson S.G.E., Forsman M., Titball R.W.;
RT   "The complete genome sequence of Francisella tularensis, the causative
RT   agent of tularemia.";
RL   Nat. Genet. 37:153-159(2005).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; AJ749949; CAG45410.1; -; Genomic_DNA.
DR   RefSeq; WP_003020656.1; NZ_CP010290.1.
DR   RefSeq; YP_169784.1; NC_006570.2.
DR   AlphaFoldDB; Q5NGQ8; -.
DR   SMR; Q5NGQ8; -.
DR   IntAct; Q5NGQ8; 3.
DR   STRING; 177416.FTT_0777; -.
DR   DNASU; 3191927; -.
DR   EnsemblBacteria; CAG45410; CAG45410; FTT_0777.
DR   KEGG; ftu:FTT_0777; -.
DR   eggNOG; COG0322; Bacteria.
DR   OMA; HIECFDN; -.
DR   Proteomes; UP000001174; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..612
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000227430"
FT   DOMAIN          20..98
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          208..243
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   612 AA;  70297 MW;  0F501487E293AE76 CRC64;
     MIVDNSKDFD LKSFLANLTT HSGVYRMLDK HGEIIYVGKA KNLKNRVNSY FSKGAKDSKT
     LMMVEQIARI EITITPSDYE AYLLENNLIK QHRPKYNILF KDDKSYPYLV ISRDKFPRVS
     FYRSKSAYKK GQCFGPYVSI SSVKNTLNTI QKIFPIRQCE NSYYKSRVRP CLQYQIKCCL
     APCVGLVSQQ QYDEQLAILK KFLAGKFSSV LEEISAKMYQ ASEDMEYEKA QVYRDQLVVL
     RKLQQQQIVD IQEDKTFDVI GIYMQDSYAS IALLQIQNGD VVADRHWSID AKGQDKTSIM
     HAFLSHFYLG DEIRNIWPKN IILSKVEFAD ITDLMNSISQ KIGQAINWII APAADNLKWL
     KLAEVNARQK LNIYTSSKSQ YQKRLESLKE FLELEKDIKR IECFDISHFQ GEATIASCVV
     YTDDGEDRKS HRRYNIKDIK SGDDYAAIHQ AVSRRVSSGL EADNLPDVMI IDGGKGQIHQ
     AEAVFREYGI QDKVQLVSLG KGIERISGKE KIYKGFDDTE YTLDEHNPGF LLLRQVRDSA
     HDHAIKGQRK KVSANRQSSI IEEIEGVGPK RRKALMMYFG GWQELSRASV DEIAKVKGIS
     KKLAQEIWEC FH