UVRC_GEOKA
ID UVRC_GEOKA Reviewed; 590 AA.
AC Q5KWH6;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=GK2675;
OS Geobacillus kaustophilus (strain HTA426).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus;
OC Geobacillus thermoleovorans group.
OX NCBI_TaxID=235909;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HTA426;
RX PubMed=15576355; DOI=10.1093/nar/gkh970;
RA Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H.,
RA Matsui S., Uchiyama I.;
RT "Thermoadaptation trait revealed by the genome sequence of thermophilic
RT Geobacillus kaustophilus.";
RL Nucleic Acids Res. 32:6292-6303(2004).
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC lesion. The N-terminal half is responsible for the 3' incision and the
CC C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC Rule:MF_00203}.
CC -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC {ECO:0000255|HAMAP-Rule:MF_00203}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC Rule:MF_00203}.
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DR EMBL; BA000043; BAD76960.1; -; Genomic_DNA.
DR RefSeq; WP_011232149.1; NC_006510.1.
DR PDB; 1YD6; X-ray; 2.00 A; A/B/C/D=1-99.
DR PDB; 3C65; X-ray; 1.90 A; A=369-590.
DR PDBsum; 1YD6; -.
DR PDBsum; 3C65; -.
DR AlphaFoldDB; Q5KWH6; -.
DR SMR; Q5KWH6; -.
DR STRING; 235909.GK2675; -.
DR PRIDE; Q5KWH6; -.
DR EnsemblBacteria; BAD76960; BAD76960; GK2675.
DR KEGG; gka:GK2675; -.
DR eggNOG; COG0322; Bacteria.
DR HOGENOM; CLU_014841_3_2_9; -.
DR OMA; HIECFDN; -.
DR EvolutionaryTrace; Q5KWH6; -.
DR Proteomes; UP000001172; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.420.340; -; 1.
DR Gene3D; 3.40.1440.10; -; 1.
DR HAMAP; MF_00203; UvrC; 1.
DR InterPro; IPR000305; GIY-YIG_endonuc.
DR InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR001943; UVR_dom.
DR InterPro; IPR036876; UVR_dom_sf.
DR InterPro; IPR004791; UvrC.
DR InterPro; IPR001162; UvrC_RNase_H_dom.
DR InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR Pfam; PF01541; GIY-YIG; 1.
DR Pfam; PF02151; UVR; 1.
DR Pfam; PF08459; UvrC_HhH_N; 1.
DR SMART; SM00465; GIYc; 1.
DR SUPFAM; SSF46600; SSF46600; 1.
DR SUPFAM; SSF47781; SSF47781; 1.
DR SUPFAM; SSF82771; SSF82771; 1.
DR TIGRFAMs; TIGR00194; uvrC; 1.
DR PROSITE; PS50164; GIY_YIG; 1.
DR PROSITE; PS50151; UVR; 1.
DR PROSITE; PS50165; UVRC; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; DNA damage; DNA excision; DNA repair;
KW Excision nuclease; Reference proteome; SOS response.
FT CHAIN 1..590
FT /note="UvrABC system protein C"
FT /id="PRO_0000227432"
FT DOMAIN 14..91
FT /note="GIY-YIG"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT DOMAIN 196..231
FT /note="UVR"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT HELIX 3..10
FT /evidence="ECO:0007829|PDB:1YD6"
FT STRAND 17..22
FT /evidence="ECO:0007829|PDB:1YD6"
FT STRAND 28..35
FT /evidence="ECO:0007829|PDB:1YD6"
FT HELIX 37..42
FT /evidence="ECO:0007829|PDB:1YD6"
FT HELIX 43..45
FT /evidence="ECO:0007829|PDB:1YD6"
FT HELIX 51..59
FT /evidence="ECO:0007829|PDB:1YD6"
FT STRAND 61..67
FT /evidence="ECO:0007829|PDB:1YD6"
FT HELIX 71..85
FT /evidence="ECO:0007829|PDB:1YD6"
FT HELIX 88..92
FT /evidence="ECO:0007829|PDB:1YD6"
FT HELIX 369..373
FT /evidence="ECO:0007829|PDB:3C65"
FT STRAND 379..393
FT /evidence="ECO:0007829|PDB:3C65"
FT STRAND 395..402
FT /evidence="ECO:0007829|PDB:3C65"
FT HELIX 408..410
FT /evidence="ECO:0007829|PDB:3C65"
FT STRAND 412..415
FT /evidence="ECO:0007829|PDB:3C65"
FT HELIX 424..442
FT /evidence="ECO:0007829|PDB:3C65"
FT STRAND 448..454
FT /evidence="ECO:0007829|PDB:3C65"
FT HELIX 456..468
FT /evidence="ECO:0007829|PDB:3C65"
FT STRAND 476..478
FT /evidence="ECO:0007829|PDB:3C65"
FT STRAND 490..492
FT /evidence="ECO:0007829|PDB:3C65"
FT TURN 493..496
FT /evidence="ECO:0007829|PDB:3C65"
FT STRAND 497..499
FT /evidence="ECO:0007829|PDB:3C65"
FT HELIX 506..521
FT /evidence="ECO:0007829|PDB:3C65"
SQ SEQUENCE 590 AA; 67840 MW; E632520E1C28C772 CRC64;
MNERLKEKLA VLPEQPGCYL MKDKHGTVIY VGKAKSLKAR VRSYFTGTHD GKTQRLVEEI
ADFEYIVTSS NAEALILEMN LIKKHDPKYN VMLKDDKSYP FIKITAEKHP RLLITRKVKK
DGGKYFGPYP NVQAANETKK LLDRLYPLRK CSTLPSRACL YYHMGQCLAP CVHPVSDEQN
KAMVEQIVRF LNGGYEDVKR ELAEKMHEAA ETLEFERAKE YRDQIAAIEM TMEKQKMMLN
DFIDRDVFGY AYDKGWMCVQ VFFLRQGKLI ERDVSIFPLY QDPDEEMLTF LGQFYAKAHH
LKPKEVVLPS DIDGELAREL LGVAVVQPKK GKKKELVELA SKNAAIALKE KFYFIERDEE
RTIKAVERLG ERLGIPAPRR IEAFDNSNIY GADPVSALVV FLDGKPAKKE YRKYKVKTVA
GPNDYETMRE VVRRRYTRVL KEGLPLPDLI IIDGGKGHLS AVRDVLENEL GLDVPLAGLA
KDEKHRTSEL LAGDPPDVVP LDRQSQEFYL LQRIQDEVHR FAVMFHRKTR QKTMFHSVLD
DIPGVGEKRK KALLNYFGSV KKMKEATVEE LQRANIPRAV AEKIYEKLHE
