ID   UVRC_GLOVI              Reviewed;         628 AA.
AC   Q7NFD4;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=gll3592;
OS   Gloeobacter violaceus (strain ATCC 29082 / PCC 7421).
OC   Bacteria; Cyanobacteria; Gloeobacteria; Gloeobacterales; Gloeobacteraceae;
OC   Gloeobacter.
OX   NCBI_TaxID=251221;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29082 / PCC 7421;
RX   PubMed=14621292; DOI=10.1093/dnares/10.4.137;
RA   Nakamura Y., Kaneko T., Sato S., Mimuro M., Miyashita H., Tsuchiya T.,
RA   Sasamoto S., Watanabe A., Kawashima K., Kishida Y., Kiyokawa C., Kohara M.,
RA   Matsumoto M., Matsuno A., Nakazaki N., Shimpo S., Takeuchi C., Yamada M.,
RA   Tabata S.;
RT   "Complete genome structure of Gloeobacter violaceus PCC 7421, a
RT   cyanobacterium that lacks thylakoids.";
RL   DNA Res. 10:137-145(2003).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; BA000045; BAC91533.1; -; Genomic_DNA.
DR   RefSeq; NP_926538.1; NC_005125.1.
DR   RefSeq; WP_011143581.1; NC_005125.1.
DR   AlphaFoldDB; Q7NFD4; -.
DR   SMR; Q7NFD4; -.
DR   STRING; 251221.35214164; -.
DR   EnsemblBacteria; BAC91533; BAC91533; BAC91533.
DR   KEGG; gvi:gll3592; -.
DR   PATRIC; fig|251221.4.peg.3625; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_2_3; -.
DR   InParanoid; Q7NFD4; -.
DR   OMA; HIECFDN; -.
DR   OrthoDB; 1036075at2; -.
DR   PhylomeDB; Q7NFD4; -.
DR   Proteomes; UP000000557; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR041663; DisA/LigA_HHH.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF12826; HHH_2; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..628
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000227434"
FT   DOMAIN          20..99
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          209..244
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   628 AA;  70535 MW;  11A35E15FEA74D9A CRC64;
     MPNLIADPER LKERLELLPT SAGVYLMRDE AGEILYVGKA KNLRNRVRSY FQPGHDHSPR
     IAIMVGKVHD FELILTDTEA EALVLEDNLI KTHKPRYNVL LKDDKQYPYL CITWSEEYPR
     IFVTRRRGSG HPEDRYFGPY TDAGALHSTL GLLKKLFPLR QRNTPVFKDR PCINYEMGRC
     PGLCQRLISP QEYRATIRQI QMILQGRTAE LLAQLEDQMQ TAAAAMNFEH AARLRDRITG
     LNQLGAHQKI TVPDSSVSRD AVALAADAAL VSIQLFQVRS GKLIGRLGFS AAASGEDPGH
     ILQRVLEEHY RASASEEIPL EVLTQHPLPE ADILATWLAE KKGRKVEIHA PQRQIKAELV
     EMVARNAEAE LQRLERFSRR QEKGLLNLAE ALELPSVPRR MECYDISHIQ GTDTVASRVV
     FVDGAPAKQY YRHYKIRDPR IVAGRPDDFA SMAEVISRRF ARAESEPEGD LPDLVVIDGG
     KGQLSAARAV MEELSYGDVP TIGLAKRLEE VFLPGRSDPV LIAQGDPALH LLQRIRDEAH
     RFAVSFHREQ RGKRMTRSSL DDIPGIGPAK RKILLDTFRS VPVLEKASFE EIAKTPGIGS
     RLAQVIHTYF HGEPEAVARA LEAEQAAN