CAF1D_ARATH
ID CAF1D_ARATH Reviewed; 302 AA.
AC Q9C6M9; Q9C7G3;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Putative CCR4-associated factor 1 homolog 4;
DE EC=3.1.13.4;
GN Name=CAF1-4; OrderedLocusNames=At1g27890; ORFNames=F13K9.1, F28L5.5;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- FUNCTION: Ubiquitous transcription factor required for a diverse set of
CC processes. It is a component of the CCR4 complex involved in the
CC control of gene expression (By similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage of poly(A) to 5'-AMP.; EC=3.1.13.4;
CC -!- COFACTOR:
CC Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC Evidence={ECO:0000250};
CC -!- SUBUNIT: Component of the CCR4-NOT complex, at least composed of CRR4
CC and CAF1 proteins. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CAF1 family. {ECO:0000305}.
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DR EMBL; AC069471; AAG51471.1; -; Genomic_DNA.
DR EMBL; AC079280; AAG50583.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE30888.1; -; Genomic_DNA.
DR PIR; B86404; B86404.
DR RefSeq; NP_174110.1; NM_102554.2.
DR AlphaFoldDB; Q9C6M9; -.
DR SMR; Q9C6M9; -.
DR BioGRID; 24917; 1.
DR STRING; 3702.AT1G27890.1; -.
DR iPTMnet; Q9C6M9; -.
DR PaxDb; Q9C6M9; -.
DR PRIDE; Q9C6M9; -.
DR DNASU; 839682; -.
DR EnsemblPlants; AT1G27890.1; AT1G27890.1; AT1G27890.
DR GeneID; 839682; -.
DR Gramene; AT1G27890.1; AT1G27890.1; AT1G27890.
DR KEGG; ath:AT1G27890; -.
DR Araport; AT1G27890; -.
DR TAIR; locus:2010414; AT1G27890.
DR eggNOG; KOG0304; Eukaryota.
DR HOGENOM; CLU_027974_1_3_1; -.
DR InParanoid; Q9C6M9; -.
DR OMA; FHETVEQ; -.
DR OrthoDB; 931256at2759; -.
DR PhylomeDB; Q9C6M9; -.
DR PRO; PR:Q9C6M9; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9C6M9; baseline and differential.
DR GO; GO:0030015; C:CCR4-NOT core complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000932; C:P-body; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004535; F:poly(A)-specific ribonuclease activity; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0043928; P:exonucleolytic catabolism of deadenylated mRNA; IBA:GO_Central.
DR Gene3D; 3.30.420.10; -; 1.
DR InterPro; IPR039637; CNOT7/CNOT8/Pop2.
DR InterPro; IPR006941; RNase_CAF1.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR10797; PTHR10797; 1.
DR Pfam; PF04857; CAF1; 1.
DR SUPFAM; SSF53098; SSF53098; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Exonuclease; Hydrolase; Metal-binding; Nuclease; Nucleus;
KW Reference proteome; RNA-binding; Transcription; Transcription regulation.
FT CHAIN 1..302
FT /note="Putative CCR4-associated factor 1 homolog 4"
FT /id="PRO_0000371554"
FT BINDING 29
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000250"
FT BINDING 31
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000250"
FT BINDING 145
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000250"
FT BINDING 218
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000250"
SQ SEQUENCE 302 AA; 34862 MW; F19BC314E98E1174 CRC64;
MGEVWRWNKE VEMDSIRDCL KHFSSIAIDT EFPGCLKETP MDASEEIRYR DMKFNVDNTH
LIQLGFTLFD RRGITKTWEI NLSDFNEHKC FKNDKSIAFL KSNGLNLDKI GEEGIGIEEF
FRDFSQILKE KDGKITWVNF QGSYDNAYLV KGLTGGKPLP ETKEEFHETV EQLLGKFVFD
VKKIAESCSG LSSRFGLQRI ADVLQMKRVG KAHHAGSDSE LTARVFTKLT FDLLNSRKQC
VRRVDHQQYQ LEQQQLMMTR CYIPIPIPIP RPRSVMFAAH HPNPYFGGGY FGMPVQGRNY
VL
