ID   UVRC_GRABC              Reviewed;         644 AA.
AC   Q0BPX7;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203};
GN   OrderedLocusNames=GbCGDNIH1_2227;
OS   Granulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodospirillales;
OC   Acetobacteraceae; Granulibacter.
OX   NCBI_TaxID=391165;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1260 / CGDNIH1;
RX   PubMed=17827295; DOI=10.1128/jb.00793-07;
RA   Greenberg D.E., Porcella S.F., Zelazny A.M., Virtaneva K., Sturdevant D.E.,
RA   Kupko J.J. III, Barbian K.D., Babar A., Dorward D.W., Holland S.M.;
RT   "Genome sequence analysis of the emerging human pathogenic acetic acid
RT   bacterium Granulibacter bethesdensis.";
RL   J. Bacteriol. 189:8727-8736(2007).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CP000394; ABI63125.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q0BPX7; -.
DR   SMR; Q0BPX7; -.
DR   STRING; 391165.GbCGDNIH1_2227; -.
DR   EnsemblBacteria; ABI63125; ABI63125; GbCGDNIH1_2227.
DR   KEGG; gbe:GbCGDNIH1_2227; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_0_5; -.
DR   OMA; HIECFDN; -.
DR   Proteomes; UP000001963; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..644
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000264898"
FT   DOMAIN          42..120
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          231..266
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   644 AA;  71389 MW;  23E9ABF012A31F2B CRC64;
     MTMPDAPANP PKEADNPSLP IVEAPPGKGV TVIEAMLKLL PDRPGVYRML DGQGEALYVG
     KARSLKKRVA SYTQIHRLPE RLRRMVSETV SMEIVTTHTE AEALLLEANL IKRLKPRFNI
     VLRDDKSYPW LMLTEDHAFP QIMKHRGAQT RKAASYWGPF ASAWAVNQTV TAMQRIFLLR
     SCSDSVFANR SRPCLLFQIR RCSAPCVDRI SQEDYAELVD QARAFLSGRG TEIQRDLARQ
     MEQAAEALEF ERAAAIRDRI RGLTHVQGTA VVNPASIGNA DVIAVWQDAG QSCVQVFFIR
     GGHNNGNRAF YPAHTSAETA QDVLGAFIAQ FYDDKPPPPL LLLNHTIAEQ ELVSEALSLK
     AGRRVELHVP VRGEKRAVVA HAETNAREAL ERKLAESAGQ NRLLDGVAEL FDLPTRPNRI
     EIYDNSHIMG TNPYGVMVVA GPEGWNKSAY RKFSIRGPIT PGDDFAMMRE MLERRFSRGL
     KERAEGPEGE ANWPDLVLID GGAGQLSAVR GILDEIGVTD VKLVAIAKGP DRDAGREWFH
     TEGQAPFQLP PRDPVLYYLQ RLRDEAHRFA ITTHRAGRSK TLVRSELDDI DGIGAARKRA
     LLNHFGSARG VKQAGLAALE ATPGISKETA RRIYAHFHPG ARAD