ID   UVRC_HALLT              Reviewed;         592 AA.
AC   B9LUM9;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=Hlac_2725;
OS   Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM
OS   34).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC   Halorubraceae; Halorubrum.
OX   NCBI_TaxID=416348;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34;
RX   PubMed=27617060; DOI=10.1186/s40793-016-0194-2;
RA   Anderson I.J., DasSarma P., Lucas S., Copeland A., Lapidus A.,
RA   Del Rio T.G., Tice H., Dalin E., Bruce D.C., Goodwin L., Pitluck S.,
RA   Sims D., Brettin T.S., Detter J.C., Han C.S., Larimer F., Hauser L.,
RA   Land M., Ivanova N., Richardson P., Cavicchioli R., DasSarma S.,
RA   Woese C.R., Kyrpides N.C.;
RT   "Complete genome sequence of the Antarctic Halorubrum lacusprofundi type
RT   strain ACAM 34.";
RL   Stand. Genomic Sci. 11:70-70(2016).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CP001365; ACM58296.1; -; Genomic_DNA.
DR   RefSeq; WP_015911406.1; NC_012029.1.
DR   AlphaFoldDB; B9LUM9; -.
DR   SMR; B9LUM9; -.
DR   STRING; 416348.Hlac_2725; -.
DR   PRIDE; B9LUM9; -.
DR   EnsemblBacteria; ACM58296; ACM58296; Hlac_2725.
DR   GeneID; 7401336; -.
DR   KEGG; hla:Hlac_2725; -.
DR   eggNOG; arCOG00873; Archaea.
DR   eggNOG; arCOG04753; Archaea.
DR   HOGENOM; CLU_014841_3_1_2; -.
DR   OMA; HIECFDN; -.
DR   Proteomes; UP000000740; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   SOS response.
FT   CHAIN           1..592
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_1000200611"
FT   DOMAIN          15..90
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          198..233
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   592 AA;  65187 MW;  BD45A8B9782F564B CRC64;
     MDADAVRERA ADLPTEPGVY QFRAGETTLY VGKAVNLRNR VRSYADPRSG RIRGMVGRAD
     RIEFAVTDTE TQALLLEANL IKRLRPRYNV RLKDDKSYPL VAITDHPVPR IEVTRDPEEG
     AVAYGPFTSK GRVETVVKAI RDEYRLRGCS DHKYANRDRP CLDYEMGICS APCTGEIDPE
     SYAEDVAAAR RFFEGETGVL ADPLRRRMEA AAENAEFERA ANLRDRLEAV EAFHGEGGEA
     VSDHSDDRTV DVLAAAVEGD TARVARLHSE RGQLVDRSRH RLDAAAVGDD GEGDEDGFAD
     PDANTPAAVL SAFLTQYYAE REFPDAILLA ERPSDPDVID WLEAEGVSVR VPGAGREAKL
     VELALKNARK RGGREDPVGA LGERLGIDRP ARIEGFDVSH AQGTAVVGSD VCFVDGSAET
     SDYRRKKLTD RNDDYANMRE LVRWRAERAV AGEDDRPDPD LLLIDGGGGQ LGAARDALAE
     TGWDVPVVAL AKAEELVVTP TGTRRWPDDA PELHLLQRVR DEAHRFAVSY HQTVRDEVKT
     VLDDVPGVGP QTRRRLLRRF GSVESVRDAS LDDLTDVDGV GDATADTLRE RL