ID   UVRC_HALMA              Reviewed;         581 AA.
AC   Q5UY89;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=rrnAC3041;
OS   Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM
OS   B-1809) (Halobacterium marismortui).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Haloarculaceae; Haloarcula.
OX   NCBI_TaxID=272569;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809;
RX   PubMed=15520287; DOI=10.1101/gr.2700304;
RA   Baliga N.S., Bonneau R., Facciotti M.T., Pan M., Glusman G., Deutsch E.W.,
RA   Shannon P., Chiu Y., Weng R.S., Gan R.R., Hung P., Date S.V., Marcotte E.,
RA   Hood L., Ng W.V.;
RT   "Genome sequence of Haloarcula marismortui: a halophilic archaeon from the
RT   Dead Sea.";
RL   Genome Res. 14:2221-2234(2004).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; AY596297; AAV47764.1; -; Genomic_DNA.
DR   RefSeq; WP_011224582.1; NZ_CP039138.1.
DR   AlphaFoldDB; Q5UY89; -.
DR   SMR; Q5UY89; -.
DR   STRING; 272569.rrnAC3041; -.
DR   EnsemblBacteria; AAV47764; AAV47764; rrnAC3041.
DR   GeneID; 40153864; -.
DR   KEGG; hma:rrnAC3041; -.
DR   PATRIC; fig|272569.17.peg.3591; -.
DR   eggNOG; arCOG00873; Archaea.
DR   eggNOG; arCOG04753; Archaea.
DR   HOGENOM; CLU_014841_3_1_2; -.
DR   OMA; HIECFDN; -.
DR   Proteomes; UP000001169; Chromosome I.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..581
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000138365"
FT   DOMAIN          15..94
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          202..237
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   581 AA;  64431 MW;  E7BCA507033CBF08 CRC64;
     MDADEVRERA GSLPREPGVY LFEQGRDDKR RVLYVGKAVD LRDRVRSYAD PRSERIAKMV
     ERAETIDFAV TDTETQALLL EANLIKRHRP PYNVRLKDDK SYPLVQLTDH PVPRIEVTRD
     PADGATVYGP FTDKGRVETV VKALREAYGL RGCSDHKYSN RDRPCLDYEM GICTAPCTGE
     IGEADYAEDA EAVTRYFEGE TGVLADPLRR EMEAAAQNQE FERAANLRDK LGAVEALHGE
     GDTAVSDSGG YQTTDVLGAA IEGERAIVAR LHAEGGKLVE RDRHTLEAPD GEGTAGVYRA
     FIPQYYAERE LPDRILCAEA PADPDIEAWL ESEGVTLGVP GAGREATLVD LALKNARQRG
     GTDDESGRLA DALGIDHPSR IEGFDVSHAQ GRSAVGSNVT FVDETPEKSD YRRKKLTEQN
     DDYANMRELL RWRATRAVEG RDDRPDPDLL LIDGGDGQLG AARDALAETG WDVPAIALAK
     DEELVITPDR VYDWNDDAPQ LHLLQRIRDE AHRFAVQYHQ TLRDEVSTTL DDVPGIGPET
     RKRLLRRFGS VDSVRAASDE ELTAIDGIGE QTAETIRTRL Q