ID   UVRC_HALS3              Reviewed;         590 AA.
AC   B0R7R3;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=OE_4344F;
OS   Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=478009;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29341 / DSM 671 / R1;
RX   PubMed=18313895; DOI=10.1016/j.ygeno.2008.01.001;
RA   Pfeiffer F., Schuster S.C., Broicher A., Falb M., Palm P., Rodewald K.,
RA   Ruepp A., Soppa J., Tittor J., Oesterhelt D.;
RT   "Evolution in the laboratory: the genome of Halobacterium salinarum strain
RT   R1 compared to that of strain NRC-1.";
RL   Genomics 91:335-346(2008).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; AM774415; CAP14782.1; -; Genomic_DNA.
DR   RefSeq; WP_010903778.1; NC_010364.1.
DR   AlphaFoldDB; B0R7R3; -.
DR   SMR; B0R7R3; -.
DR   PRIDE; B0R7R3; -.
DR   EnsemblBacteria; CAP14782; CAP14782; OE_4344F.
DR   GeneID; 5953362; -.
DR   KEGG; hsl:OE_4344F; -.
DR   HOGENOM; CLU_014841_3_1_2; -.
DR   OMA; HIECFDN; -.
DR   PhylomeDB; B0R7R3; -.
DR   Proteomes; UP000001321; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   SOS response.
FT   CHAIN           1..590
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_1000099487"
FT   DOMAIN          15..98
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          207..242
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   590 AA;  63698 MW;  3F685DB0C4B1B500 CRC64;
     MNGDEVRARA SELPAEPGVY QFVARDPDGT ADGERVLYVG KAVDIRDRVR SYGDPRSERI
     AGMVARADDV TVAVTDTETQ ALLLEANLVK RHQPRYNVRL KDDKSYPLVQ VTSHREAPRI
     EVTRDPDPGA AAFGPYTDKG DVETVVKAVR SVYGLRGCSE HKYRDRERPC LDYEMGLCAA
     PCTGAISERE YREAVESATR FFEGETGALA DPLRREMAAA AQAEAFERAA NLRDRLAVVE
     GFHEGGGAAV AAGDADAGAS TDVLGVAVEG DAATVARLHA EGGQLVERDQ HRLEAPQGED
     RVAAVLAAFL VQYYAERDLP ERILLPEPHG DDEVAAWLDA ADVAVGVPGA GREARLVELA
     LKNAHRRAGG GDELGALADA LGVRRPERIE GVDVSHAQGR EVVGSNVCFV DGSAETADYR
     RKKLDEENDD YANMRRLVGW RAERAVDGRD DRPDPDVLLV DGGRGQLDAA LDAVEAAGWD
     GPDAVIALAK DEEVVVTPDR TYDWGSDAPQ LHVLQRVRDE AHRFAVAYHR TLRDDVTTAL
     DGITGVGPEL RARLLGRFGS VAGVRQASVK DLRDVAGVGE ATAETIAKRL