ID   UVRC_HALWD              Reviewed;         585 AA.
AC   Q18E52;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=HQ_3694A;
OS   Haloquadratum walsbyi (strain DSM 16790 / HBSQ001).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC   Haloferacaceae; Haloquadratum.
OX   NCBI_TaxID=362976;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 16790 / HBSQ001;
RX   PubMed=16820047; DOI=10.1186/1471-2164-7-169;
RA   Bolhuis H., Palm P., Wende A., Falb M., Rampp M., Rodriguez-Valera F.,
RA   Pfeiffer F., Oesterhelt D.;
RT   "The genome of the square archaeon Haloquadratum walsbyi: life at the
RT   limits of water activity.";
RL   BMC Genomics 7:169-169(2006).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; AM180088; CAJ53781.1; -; Genomic_DNA.
DR   RefSeq; WP_011572863.1; NC_008212.1.
DR   AlphaFoldDB; Q18E52; -.
DR   SMR; Q18E52; -.
DR   STRING; 362976.HQ_3694A; -.
DR   PRIDE; Q18E52; -.
DR   EnsemblBacteria; CAJ53781; CAJ53781; HQ_3694A.
DR   GeneID; 4194927; -.
DR   KEGG; hwa:HQ_3694A; -.
DR   eggNOG; arCOG04753; Archaea.
DR   HOGENOM; CLU_014841_3_1_2; -.
DR   OMA; HIECFDN; -.
DR   Proteomes; UP000001975; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..585
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000264982"
FT   DOMAIN          15..90
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          198..233
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   585 AA;  64789 MW;  D2B5B375F13F5FE6 CRC64;
     MKQRELRERA AELPAEPGVY QFLEDNTVRY VGKALELRDR VRSYADPRSE RIRQMVARAD
     DIDIALTETE TQALLLEANL IKRHQPRYNV RLKDDKSYPL VQFTNHSVPR IEVTRDPDSD
     ATVFGPYTEV KRLETAVKAL REVYGLRGCS DHKYNNRNRP CLEYEVGLCS APCTGEIDAT
     AYRSAVESAV QFFEGKTGIL ADPLRQEMQA AATAEEFERA ANIRDRLAVI ESFHGGGEAA
     VSSEDNSHTA ETTSERAVDV LGVAIEGTTA TVARLHSDNG QLVDRSQHRL NAPTGEDRAS
     AVLTAFLTQY YAERSLPDAI LCSEHPHDND VREWLSVEGV NIRVPGTGRE SKLIDLALKN
     ARNGSVHDNE SAALADALGF SIINRIEGFD VSHSQGRAVV GSNVCFIDGS AATDAYRRKR
     LTDTNDDYAR MQELLTWRAK RACDGRDERP DPDLIVIDGG KGQLRAAREA VETTGWDVST
     IALAKADELV VTPNGVHDWD ADAPQLHLLQ RVRDEAHRFA VQYHQSIRDD IHTVLSDVPG
     VGEQTQQALL RRFGSVENVR SASRDALCDV PGVGKQTADT IANRL