ID   UVRC_HELPG              Reviewed;         594 AA.
AC   B5Z7I6;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=HPG27_780;
OS   Helicobacter pylori (strain G27).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=563041;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=G27;
RX   PubMed=18952803; DOI=10.1128/jb.01416-08;
RA   Baltrus D.A., Amieva M.R., Covacci A., Lowe T.M., Merrell D.S.,
RA   Ottemann K.M., Stein M., Salama N.R., Guillemin K.;
RT   "The complete genome sequence of Helicobacter pylori strain G27.";
RL   J. Bacteriol. 191:447-448(2009).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CP001173; ACI27535.1; -; Genomic_DNA.
DR   RefSeq; WP_000774307.1; NC_011333.1.
DR   AlphaFoldDB; B5Z7I6; -.
DR   SMR; B5Z7I6; -.
DR   EnsemblBacteria; ACI27535; ACI27535; HPG27_780.
DR   KEGG; hpg:HPG27_780; -.
DR   HOGENOM; CLU_014841_3_2_7; -.
DR   OMA; HIECFDN; -.
DR   OrthoDB; 1036075at2; -.
DR   Proteomes; UP000001735; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   SOS response.
FT   CHAIN           1..594
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_1000099489"
FT   DOMAIN          13..99
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          205..240
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   594 AA;  68592 MW;  8646206C44B3C401 CRC64;
     MADLLSSLKN LPNSSGVYQY FDKNRQLLYI GKAKNLKKRI KSYFSICNNE ITPNHRASLR
     IQMMVKQIAF LETILVENEQ DALILENSLI KQLKPKYNIL LRDDKTYPYI YMDFSTDFPI
     PLITRKILKQ PGVKYFGPFT SGAKDILDSL YELLPLVQKK NCIKDKKACM FYQIERCKAP
     CEDKITKEEY LKIAKECLEM IENKDRLIKE LELKMERLSS NLRFEEALIY RDRIAKIQKI
     APFTCMDLAK LYDLDIFAFY GASNKAVLVK MFMRGGKIIS SAFEKIHSLN GFDTDEAMKQ
     AIINHYQSHL PLIPEQILLN ACSNEALKEL QEFISHQYSK KIALSIPKKG DKLALIEIAM
     KNAQEIFSQE KTSNEDLILE EVRSLFNLEC VPYRVEIFDT SHHANSQCVG GMVVYENNEF
     QKDSYRRYHL KGSNEYAQMS ELLTRRALDF AKEPPPNLWV IDGGRAQLNI ALEILKSSGS
     FVEVIAISKE KRDSKAYRSK GGAKDIIHTP SDTFKLLPSD KRLQWVQKLR DESHRYAINF
     HRSTKLKNMK QIALLKEKGI GEASVKKLLD YFGSFEAIEK ASEQEKNAVL KKRI