ID   UVRC_HELPJ              Reviewed;         594 AA.
AC   Q9ZL21;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 118.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=jhp_0760;
OS   Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J99 / ATCC 700824;
RX   PubMed=9923682; DOI=10.1038/16495;
RA   Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C.,
RA   Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J.,
RA   Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D.,
RA   Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.;
RT   "Genomic sequence comparison of two unrelated isolates of the human gastric
RT   pathogen Helicobacter pylori.";
RL   Nature 397:176-180(1999).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; AE001439; AAD06337.1; -; Genomic_DNA.
DR   PIR; B71893; B71893.
DR   RefSeq; WP_000774433.1; NZ_CP011330.1.
DR   AlphaFoldDB; Q9ZL21; -.
DR   SMR; Q9ZL21; -.
DR   STRING; 85963.jhp_0760; -.
DR   EnsemblBacteria; AAD06337; AAD06337; jhp_0760.
DR   KEGG; hpj:jhp_0760; -.
DR   PATRIC; fig|85963.30.peg.216; -.
DR   eggNOG; COG0322; Bacteria.
DR   OMA; HIECFDN; -.
DR   Proteomes; UP000000804; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   SOS response.
FT   CHAIN           1..594
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000138306"
FT   DOMAIN          13..99
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          205..240
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   594 AA;  68672 MW;  0E63C45BA42342E7 CRC64;
     MADLLSSLKN LSSSSGVYQY FDKNRQLLYI GKAKNLKKRI KSYFSVRNNE ITPNPRTSLR
     VQMMVKQIAF LETILVENEQ DALILENSLI KQLKPKYNIL LRDDKTYPYI YMDFSIDFPI
     PLITRKILKQ PGVKYFGPFT SGAKDILDSL YELLPLVQKK NCIKDKKACM FYQIERCKAP
     CEDKITKEEY LKIAKECLEM IENKDRLIKE LELKMERLSS NLRFEEALIY RDRIAKIQKI
     APFTCMDLAK LYDLDIFAFY GGNNKAVLVK MFMRGGKIIS SAFEKIHSLN GFDTDEAMKQ
     AIINHYQSHL PLMPEQILLS ACSNETLKEL QEFISHQYSK KIALSIPKKG DKLALIEIAM
     KNAQEIFSQE KTSNEDRILE EARSLFNLEC VPYRVEIFDT SHHSNSQCVG GMVVYENNAF
     QKDSYRRYHL KGSNEYDQMS ELLTRRALDF AKEPPPNLWV IDGGRAQLNI ALEILKSSGS
     FVEVIAISKE KRDSKAYRSK GGAKDIIHTI SHTFKLLPSD KRLQWVQKLR DESHRYAINF
     HRSTKLKNMK QIALLKEKGI GEASVKKLLD YFGSFEAIEK ASDQEKNAVL KKRK