ID   UVRC_KOCRD              Reviewed;         689 AA.
AC   B2GH80;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=KRH_12060;
OS   Kocuria rhizophila (strain ATCC 9341 / DSM 348 / NBRC 103217 / DC2201).
OC   Bacteria; Actinobacteria; Micrococcales; Micrococcaceae; Kocuria.
OX   NCBI_TaxID=378753;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 9341 / DSM 348 / NBRC 103217 / DC2201;
RX   PubMed=18408034; DOI=10.1128/jb.01853-07;
RA   Takarada H., Sekine M., Kosugi H., Matsuo Y., Fujisawa T., Omata S.,
RA   Kishi E., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.;
RT   "Complete genome sequence of the soil actinomycete Kocuria rhizophila.";
RL   J. Bacteriol. 190:4139-4146(2008).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; AP009152; BAG29553.1; -; Genomic_DNA.
DR   RefSeq; WP_012398274.1; NC_010617.1.
DR   AlphaFoldDB; B2GH80; -.
DR   SMR; B2GH80; -.
DR   STRING; 378753.KRH_12060; -.
DR   PRIDE; B2GH80; -.
DR   EnsemblBacteria; BAG29553; BAG29553; KRH_12060.
DR   KEGG; krh:KRH_12060; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_2_11; -.
DR   OMA; HIECFDN; -.
DR   OrthoDB; 1036075at2; -.
DR   Proteomes; UP000008838; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..689
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_1000099494"
FT   DOMAIN          16..95
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          208..243
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   REGION          316..337
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   689 AA;  76431 MW;  2309CD08695D1FA7 CRC64;
     MADPASYKPA RQDIPTNPGV YRFRDEHGRV IYVGKAKNLR NRVSSYFAPL HQLAPKTRAM
     VTTAAAVQWT VVGSEFESLQ LEYTWIKEFA PRFNIAYRDD KSYPYLAVTM SEDVPRAMVT
     RGEKKPGNRY FGPYSQAWAI RDTLDALLRV FPVRTCTTGV YQRAERSGRP CLLGYIDKCS
     APCVGNISQE EHRELADDLC RFMAGHAKPY IRELTRQMNE AAECMDFETA AARRDDVGAL
     ERVFERNTVV LTDSTDADFF AIAEDELEAA VQVFHVRGGR IRGQRGWITE KVEDVTTAQL
     MTNLLQQVYG EAQSGLAPAA SGRRRTARHG SEDVVGQHRR TSELAYRQDT IPRAVHVSVL
     PDEADEIRAW LSELRGSQVT VQRPQRGDKA QLLETVAENA RQALTLHKSR RAGDLTTRSA
     SLQQLQEALG LPDALMRIEC YDISHVQGTN VVASMVVFED GLPRKSEYRK FSITGDAARD
     DTASMYDVIH RRFSRHVEQQ RRAAEKGVST GEVAADDDEG TTRAFAYPPN LVIVDGGPPQ
     VAAAQRALDD LRVTDVHVVG LAKRLEEVWV PDDEFPVILP RASEGLFLMQ RVRDEAHRFA
     ITFHRQKRSK AMTVSALDEV PGLGPAKQKA LLKHFGSVKK LRAATAEQIL EVKGFGPALA
     VKVAQALGGE AAASSTAPAV DTGTGELLD