ID   UVRC_KORVE              Reviewed;         610 AA.
AC   Q1ILY2;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2006, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203};
GN   OrderedLocusNames=Acid345_3117;
OS   Koribacter versatilis (strain Ellin345).
OC   Bacteria; Acidobacteria; Acidobacteriales; Acidobacteriaceae;
OC   Candidatus Koribacter.
OX   NCBI_TaxID=204669;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ellin345;
RX   PubMed=19201974; DOI=10.1128/aem.02294-08;
RA   Ward N.L., Challacombe J.F., Janssen P.H., Henrissat B., Coutinho P.M.,
RA   Wu M., Xie G., Haft D.H., Sait M., Badger J., Barabote R.D., Bradley B.,
RA   Brettin T.S., Brinkac L.M., Bruce D., Creasy T., Daugherty S.C.,
RA   Davidsen T.M., DeBoy R.T., Detter J.C., Dodson R.J., Durkin A.S.,
RA   Ganapathy A., Gwinn-Giglio M., Han C.S., Khouri H., Kiss H., Kothari S.P.,
RA   Madupu R., Nelson K.E., Nelson W.C., Paulsen I., Penn K., Ren Q.,
RA   Rosovitz M.J., Selengut J.D., Shrivastava S., Sullivan S.A., Tapia R.,
RA   Thompson L.S., Watkins K.L., Yang Q., Yu C., Zafar N., Zhou L., Kuske C.R.;
RT   "Three genomes from the phylum Acidobacteria provide insight into the
RT   lifestyles of these microorganisms in soils.";
RL   Appl. Environ. Microbiol. 75:2046-2056(2009).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CP000360; ABF42118.1; -; Genomic_DNA.
DR   RefSeq; WP_011523917.1; NC_008009.1.
DR   AlphaFoldDB; Q1ILY2; -.
DR   SMR; Q1ILY2; -.
DR   STRING; 204669.Acid345_3117; -.
DR   EnsemblBacteria; ABF42118; ABF42118; Acid345_3117.
DR   KEGG; aba:Acid345_3117; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_2_0; -.
DR   OMA; HIECFDN; -.
DR   OrthoDB; 1036075at2; -.
DR   Proteomes; UP000002432; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..610
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000264859"
FT   DOMAIN          12..91
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          202..237
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   610 AA;  70175 MW;  9F6880E3BC79566D CRC64;
     MDLHQKIRTL PTSPGVYLYK NAEGEIIYVG KAKNLRSRVG SYFVRGADEN SKTGSLLREA
     VDVEYIVVDN EKEALALENN LIKQKKPRFN ILLRDDKTYP YIKLTMGEKW PRVYVTRRLK
     KDGSEYYGPF FPANLAYRVV DLIHRNFLVP SCYIDLRRYH PRPCLQHYIG RCLGPCVEGL
     TNEVQYGEAV KDVKLFLEGR HSDLKQSLTA RMNKAAEGMQ FELAAKYRDL ITTVEDLHQK
     QRIAAAEGDD ADVFGYHYEN HMVAVNLFHM RGGKVLDRRD FFFEDLGEME ATGGLNTGEF
     FSTLLQQIYL DNKYVPRTIY VPVEFEDREA LCEILSEQMH RKIDINVPQR GDKRSLIDLV
     AQNAKQSYDQ RFRVMRPQTD VLKSVLQDTL ELPELPNRIE CFDISHIQGA ETVASMVVWE
     DGKMKKSDYR KFIIKTVQGV DDFASMREVV TRRYKRIVEE NQPMPSLVLI DGGVGQLHAA
     AGALEAIGIT NQPLASIAKR EEIIYVHGRE DEPIRIDHHS PVLHIIQLIR DEAHRFAITF
     HRKRREIRDR SNELLEIPGI GEQAMKRLLR HFGSIQSIRT ANATSLEAVV NRTQAEAILA
     HFRAEETTRS