ID   UVRC_LACAC              Reviewed;         600 AA.
AC   Q5FKH6;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=LBA0946;
OS   Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=272621;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700396 / NCK56 / N2 / NCFM;
RX   PubMed=15671160; DOI=10.1073/pnas.0409188102;
RA   Altermann E., Russell W.M., Azcarate-Peril M.A., Barrangou R., Buck B.L.,
RA   McAuliffe O., Souther N., Dobson A., Duong T., Callanan M., Lick S.,
RA   Hamrick A., Cano R., Klaenhammer T.R.;
RT   "Complete genome sequence of the probiotic lactic acid bacterium
RT   Lactobacillus acidophilus NCFM.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:3906-3912(2005).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CP000033; AAV42798.1; -; Genomic_DNA.
DR   RefSeq; WP_003547051.1; NC_006814.3.
DR   RefSeq; YP_193829.1; NC_006814.3.
DR   AlphaFoldDB; Q5FKH6; -.
DR   SMR; Q5FKH6; -.
DR   STRING; 272621.LBA0946; -.
DR   PRIDE; Q5FKH6; -.
DR   EnsemblBacteria; AAV42798; AAV42798; LBA0946.
DR   GeneID; 56942565; -.
DR   KEGG; lac:LBA0946; -.
DR   PATRIC; fig|272621.13.peg.897; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_2_9; -.
DR   OMA; HIECFDN; -.
DR   BioCyc; LACI272621:G1G49-948-MON; -.
DR   Proteomes; UP000006381; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..600
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000227438"
FT   DOMAIN          15..92
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          197..232
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   600 AA;  69255 MW;  DC4F3FB917FB2C96 CRC64;
     MATELIENKL KLLPEKPGCY LMKDINGTVI YVGKSKNLKN RVRSYFKSKQ VGRRAELVRE
     IRDYDIITVS TDKEAFLLEI TLIKKYQPYY NVQLKQGTGY PYIEITREHD PQTRLTSVVH
     KDGGYYFGPY PNVYAAQATL KFIRKVYPLR RCHGYQGRPC LYYHMGQCLG ACFKKVPQKE
     YDEQIKKIKS FLNGDITSVK QDLTTKMEKA SENLEFERAA EIRDQLKYIE ETVEKQKIIS
     NDNTQRDIFN YYVDKSWISI QIFFLRQAKL LRRETRMFPL TDAADPEDAF TSFIVQFYGQ
     KNRILPKEIL IPSGFDDDTL AEVLNVAVRT PQRGQKKSLL DMAKDNAKLK LDDKFRLLEL
     GNRKTKGAQK EIFDALGLPY GHVIESFDHS HIQGADPVSA LVVFKDGEPD KTSYRKYKLK
     GEVEHQNGGD EVRNTREVVR RRYGRLLREH KKMPDLILMD GGQIQVDACE DVLRNELNLN
     IPVAGMVKDD KHRTNHLLFG DPINGIPLKL IPLDPKSEGF YLMTRIQDEV HRFAITFHRR
     RHAKNALSSR LDSIKGIGPK SRNKLLRNFG SLKKIKEASI EDLRAAGLTL PQAQTVKLML