ID   UVRC_LACJO              Reviewed;         600 AA.
AC   Q74JN8;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 113.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=LJ_1070;
OS   Lactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=257314;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CNCM I-1225 / La1 / NCC 533;
RX   PubMed=14983040; DOI=10.1073/pnas.0307327101;
RA   Pridmore R.D., Berger B., Desiere F., Vilanova D., Barretto C.,
RA   Pittet A.-C., Zwahlen M.-C., Rouvet M., Altermann E., Barrangou R.,
RA   Mollet B., Mercenier A., Klaenhammer T., Arigoni F., Schell M.A.;
RT   "The genome sequence of the probiotic intestinal bacterium Lactobacillus
RT   johnsonii NCC 533.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2512-2517(2004).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; AE017198; AAS08891.1; -; Genomic_DNA.
DR   RefSeq; WP_011161921.1; NC_005362.1.
DR   AlphaFoldDB; Q74JN8; -.
DR   SMR; Q74JN8; -.
DR   STRING; 257314.LJ_1070; -.
DR   EnsemblBacteria; AAS08891; AAS08891; LJ_1070.
DR   KEGG; ljo:LJ_1070; -.
DR   PATRIC; fig|257314.6.peg.930; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_2_9; -.
DR   OMA; HIECFDN; -.
DR   Proteomes; UP000000581; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..600
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000227439"
FT   DOMAIN          15..92
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          197..232
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   600 AA;  69328 MW;  BE6CD80BC81D95BC CRC64;
     MATEHIENKL KLLPDKPGCY LMKDVNGNVI YVGKSKNLKN RVRSYFKSKQ VGRRAELVRE
     IRDFDIITVS SDKESFLLEI TLIKKYQPYY NVQLKQGTGY PYIEITNERD PQTRLTSIVH
     KDHGYYFGPY PNVYAAQATL KFIQKVWPLR RCTGHQGRPC LYYHMGQCLG ACFKEVPKST
     YDAQIRKIKR FLNGDIAQVK QDLTEKMTQA SMDLEFERAA EIRDQLKYIE QTVEKQKIIS
     NDHTQRDIFN FYVDKSWISI QIFFLRQAKL LRRETRLFPL TDTNDPQDAF VSFIAQFYGQ
     RNRVLPKEVL VPAGMDNESL SEVLKVPVRT PQRGQKKALL EMAHDNAKLK LDEKFRLLEL
     GNRKTKGAQK EIFDALGLPY GHRIESFDHS HIQGADPVSA LVVFTDGEAD KHEYRKYKLK
     GEVEHQNAAD EVGNTREVVR RRYSRLLKEH KKMPDLILMD GGQIQVEACL DVLRNELNVN
     IPVAGMVKDD HHRTNHLIFG DPTKGEELKL IPLDPKSEGF YLMTRIQDEV HRFAITFHRR
     THAKNALSSK LDEIKGIGPK SRNKLLRKFG SLKKIKEASV DELREAGLTL PQAQTVKLSL