ID   UVRC_LACLA              Reviewed;         668 AA.
AC   Q9CH98;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   27-APR-2001, sequence version 1.
DT   25-MAY-2022, entry version 116.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=LL0840;
GN   ORFNames=L0258;
OS   Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=272623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IL1403;
RX   PubMed=11337471; DOI=10.1101/gr.gr-1697r;
RA   Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J.,
RA   Ehrlich S.D., Sorokin A.;
RT   "The complete genome sequence of the lactic acid bacterium Lactococcus
RT   lactis ssp. lactis IL1403.";
RL   Genome Res. 11:731-753(2001).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; AE005176; AAK04938.1; -; Genomic_DNA.
DR   PIR; H86729; H86729.
DR   RefSeq; NP_266996.1; NC_002662.1.
DR   RefSeq; WP_010905584.1; NC_002662.1.
DR   AlphaFoldDB; Q9CH98; -.
DR   SMR; Q9CH98; -.
DR   STRING; 272623.L0258; -.
DR   PaxDb; Q9CH98; -.
DR   EnsemblBacteria; AAK04938; AAK04938; L0258.
DR   KEGG; lla:L0258; -.
DR   PATRIC; fig|272623.7.peg.899; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_2_9; -.
DR   OMA; HIECFDN; -.
DR   Proteomes; UP000002196; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..668
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000138307"
FT   DOMAIN          14..91
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          196..231
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   668 AA;  76425 MW;  5A1BB5EF83DB042E CRC64;
     MNQTIKAKLE LLPDSPGCYL HKDKNGTVIY VGKAKNLKNR VRSYFHGSHN TKTELLVSEI
     EDLEWIVVGS NIESLVLEIN LIQRYKPKYN IMLKDDKYYP FLKITNEKYP RLLVVRKVQK
     DGATYFGPYP DVKAANEVKR LLDRIFPFRK CGLHEKKVCF YFHIHQCLCP VVNHVDPQVF
     KDMTQEVKEF LTGSDKKIVN ELEAKMMVSS DNMEFEQAAE YRDVIKAIGT LRTKQRVMNQ
     DLKDRDVFGY YVDKGWMCVQ VFFVRQGKLI QRDVNMFPYY NDAEEDFLTY IGQFYQDNNH
     MMPREIFIPQ DIDKESVEAV VAASQEGNLL TKAQAKEVDA KVFTAKTLKF SDQKDVEQSI
     VKLDKELSAE KRLSSLLAKT QIVQPSRGEK KQLVNMATKN AQSQLQLKFD VAERDILKTT
     KAVENLGKIL GIPKPVRIES FDNSNIMGTS PVSAMVVFID GKPSKKDYRK YKIKTVVGAD
     DYASMREVMT RRYSRALKEE TALPDLIAMD GGAGQVNITK QVLKELGLSI PVAGMQKNDK
     HQTSELLFGD PLDVVPLSRQ SQEFFLLTRI QDEVHRFAIT FHRQLRGKNT FSSKLDGIVG
     LGPKRKQKLL TTFKNLKAIE EASVQEVAEA DIPYEVAERV KTTLSGPIQE NENWESLKDN
     VPLLEGKK