ID   UVRC_LACLM              Reviewed;         669 AA.
AC   A2RLW6;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=llmg_1718;
OS   Lactococcus lactis subsp. cremoris (strain MG1363).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus; Lactococcus cremoris subsp. cremoris.
OX   NCBI_TaxID=416870;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MG1363;
RX   PubMed=17307855; DOI=10.1128/jb.01768-06;
RA   Wegmann U., O'Connell-Motherway M., Zomer A., Buist G., Shearman C.,
RA   Canchaya C., Ventura M., Goesmann A., Gasson M.J., Kuipers O.P.,
RA   van Sinderen D., Kok J.;
RT   "The complete genome sequence of the lactic acid bacterial paradigm
RT   Lactococcus lactis subsp. cremoris MG1363.";
RL   J. Bacteriol. 189:3256-3270(2007).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; AM406671; CAL98290.1; -; Genomic_DNA.
DR   RefSeq; WP_011835513.1; NZ_WJVF01000003.1.
DR   AlphaFoldDB; A2RLW6; -.
DR   SMR; A2RLW6; -.
DR   STRING; 416870.llmg_1718; -.
DR   EnsemblBacteria; CAL98290; CAL98290; llmg_1718.
DR   KEGG; llm:llmg_1718; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_2_9; -.
DR   OMA; HIECFDN; -.
DR   PhylomeDB; A2RLW6; -.
DR   BioCyc; LLAC416870:LLMG_RS08640-MON; -.
DR   Proteomes; UP000000364; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   SOS response.
FT   CHAIN           1..669
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_1000077800"
FT   DOMAIN          14..91
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          196..231
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   REGION          647..669
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   669 AA;  76433 MW;  2945B978A0C581EE CRC64;
     MNQTIKAKLE LLPDSPGCYL HKDKNGTVIY VGKAKNLKNR VRSYFHGSHN TKTELLVSEI
     EDLEWIVVGS NIESLVLEIN LIQRYKPKYN IMLKDDKYYP FLKITNEKYP RLLVVRKVQK
     DGATYFGPYP DVKAANEVKR LLDRIFPFRK CGLHEKKVCF YFHIHQCLCP VVNHVDPQVY
     KDMTQEVKEF LTGSDKKIVK ELEGKMISAS DNMEFEQAAE YRDVIKAIGT LRTKQRVMNQ
     DLKDRDVFGY YVDKGWMCVQ VFFVRQGKLI QRDVNMFPYY NDAEEDFLTY IGQFYQDNNH
     MMPREIFIPQ DIDKDSVEAV VAASQEGNLL TKAQAKAVDA KVFTAKTLKF SDQKDVEQSI
     VKLDKELSSE KRLSSLLAKT QIIQPSRGEK KQLVNMATKN AQTQLQLKFD VAERDILKTT
     KAVENLGKIL GIPKPVRIES FDNSNIMGTS PVSAMVVFID GKPSKKDYRK YKIKTVVGAD
     DYASMREVMT RRYSRALKEE TALPDLIAMD GGAGQVNIAK EVLRELGLAI PVAGMQKNDK
     HQTSELLFGD PLEVVPLSRQ SQEFFLLTRI QDEVHRFAIT FHRQLRGKNT FSSKLDGIVG
     LGPKRKQKLL TTFKNLKAIE EATVQEVAEA GVPYEVAERV KNTLSAPHKS DENWESIKDN
     VPLLKSEKS