ID   UVRC_LIGS1              Reviewed;         590 AA.
AC   Q1WT45;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=LSL_1098;
OS   Ligilactobacillus salivarius (strain UCC118) (Lactobacillus salivarius).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Ligilactobacillus.
OX   NCBI_TaxID=362948;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UCC118;
RX   PubMed=16617113; DOI=10.1073/pnas.0511060103;
RA   Claesson M.J., Li Y., Leahy S., Canchaya C., van Pijkeren J.P.,
RA   Cerdeno-Tarraga A.M., Parkhill J., Flynn S., O'Sullivan G.C., Collins J.K.,
RA   Higgins D., Shanahan F., Fitzgerald G.F., van Sinderen D., O'Toole P.W.;
RT   "Multireplicon genome architecture of Lactobacillus salivarius.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:6718-6723(2006).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CP000233; ABD99906.1; -; Genomic_DNA.
DR   RefSeq; WP_011476164.1; NC_007929.1.
DR   RefSeq; YP_535989.1; NC_007929.1.
DR   AlphaFoldDB; Q1WT45; -.
DR   SMR; Q1WT45; -.
DR   STRING; 362948.LSL_1098; -.
DR   PRIDE; Q1WT45; -.
DR   EnsemblBacteria; ABD99906; ABD99906; LSL_1098.
DR   KEGG; lsl:LSL_1098; -.
DR   PATRIC; fig|362948.14.peg.1170; -.
DR   HOGENOM; CLU_014841_3_2_9; -.
DR   OMA; HIECFDN; -.
DR   Proteomes; UP000006559; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..590
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000264905"
FT   DOMAIN          15..92
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          197..232
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   590 AA;  68051 MW;  CB605DC4A80DE1EA CRC64;
     MATQHIENKL KLLPDLPGCY MMKDINSRII YVGKAKNLKN RVRSYFKSSH EGKTAKLVSE
     IRNFETIITS TDKEAFLLEI TLIQKHKPYY NIKLKRGTGY PYIKITHEKD PQLKIVSQVK
     KDGGYYFGPY PNVYAATETL QLLQKVYPLR RCNGYQKRPC LYYHMGQCLG ACFKEVPQSE
     YEKQIKKIKS FLNGNVSKIK KELEQKMETA SENLEFERAA EIRDQIHYVE MTVEKQKIIS
     NDNTPRDLFA FYMNKGWLSL QIFSIRQARL MKREKRLFPC IDTPEAELES FILQFYNQKN
     RILPKEILVP SGMDKETLSE ILGIPVKTPQ RGQKRDLLEM AQKNARLVLE EKFRLLELDE
     RKTTGAMNEI TDALGLPNGH RIEAFDHSHL QGEDLVSAMV CFIDGKPEKT EYRKYKLKNV
     DHADEAASTR EVIYRRYSRL LKEKANLPDL ILMDGASIQI NAAVDVLHNQ LGIDIPVAGM
     VKNDRHKTAD LMTENDEKIG LDPKSEGFYL LQRIQDEVHR FAITFHRQVR SKNSLASRLE
     RIQGVGPKTR IKLLRNYGSL KNISAASVED LESLGISKKV AQTIKLSLKN