ID   UVRC_MALP2              Reviewed;         589 AA.
AC   Q8EWS6;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=MYPE1260;
OS   Malacoplasma penetrans (strain HF-2) (Mycoplasma penetrans).
OC   Bacteria; Tenericutes; Mycoplasmoidales; Mycoplasmoidaceae; Malacoplasma.
OX   NCBI_TaxID=272633;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HF-2;
RX   PubMed=12466555; DOI=10.1093/nar/gkf667;
RA   Sasaki Y., Ishikawa J., Yamashita A., Oshima K., Kenri T., Furuya K.,
RA   Yoshino C., Horino A., Shiba T., Sasaki T., Hattori M.;
RT   "The complete genomic sequence of Mycoplasma penetrans, an intracellular
RT   bacterial pathogen in humans.";
RL   Nucleic Acids Res. 30:5293-5300(2002).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; BA000026; BAC43918.1; -; Genomic_DNA.
DR   RefSeq; WP_011076954.1; NC_004432.1.
DR   AlphaFoldDB; Q8EWS6; -.
DR   SMR; Q8EWS6; -.
DR   STRING; 272633.26453586; -.
DR   PRIDE; Q8EWS6; -.
DR   EnsemblBacteria; BAC43918; BAC43918; BAC43918.
DR   KEGG; mpe:MYPE1260; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_2_14; -.
DR   OMA; HIECFDN; -.
DR   OrthoDB; 1036075at2; -.
DR   Proteomes; UP000002522; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..589
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000227448"
FT   DOMAIN          14..91
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   589 AA;  69271 MW;  59C9F01C991AC97E CRC64;
     MNEQIKDKLK KIPHKPGCYL WKDKNGIVIY VGKAVDLANR IKQYFLKDRD LKTKKLANEI
     CDVDYVVVNN ENESLLLENN LIAKYKPKYN MLLRESNAFP YILVTKEEHP RILYSHDSTK
     KIKGTYYGPF ANSNIKKYEL YNFINRIFPL RKCNKLPNKK CIYYDIGQCL GPCIKKVTRQ
     DYEPYLKEIN DFFSGKSKSI DEQLEKKEIQ AAEKLMFEDS QKYLELRKNL KMFSERQDII
     FSQKNDEDII GFYCKENVIS IVIFKYVNGS LLSKYDLITV FYSELDEILL TLIYEYYSKI
     AIELPKTVYL SLSDEKLKTL SESLKIKFLN PSKGVKKDVM DTAFNNAVEI MKNKYLQLIS
     NQNRELNSLE ELQKLLDIKD LYRMEIFDNS NIFNTNKVGA MVVYENGVKN KNEYRKFNIK
     DEDANSDYDY MKEVIYRRYK NNTASFGEIP NLIIVDGGKP QVKAALESLK FLELDSIIPV
     IGLAKDDKHK TDRIVKWDFS EIKLDKKSDL YFFLLNIQDE VHRFAISFYR NKKSKSLFEN
     SLYKIKNLGK TRIEKLLEKY ETLDKIKEAS VEELSQIVPI EVAKEIKKL