ID   UVRC_MESFL              Reviewed;         588 AA.
AC   Q6F216;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=Mfl101;
OS   Mesoplasma florum (strain ATCC 33453 / NBRC 100688 / NCTC 11704 / L1)
OS   (Acholeplasma florum).
OC   Bacteria; Tenericutes; Mollicutes; Entomoplasmatales; Entomoplasmataceae;
OC   Mesoplasma.
OX   NCBI_TaxID=265311;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33453 / NBRC 100688 / NCTC 11704 / L1;
RA   Birren B.W., Stange-Thomann N., Hafez N., DeCaprio D., Fisher S.,
RA   Butler J., Elkins T., Kodira C.D., Major J., Wang S., Nicol R., Nusbaum C.;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; AE017263; AAT75457.1; -; Genomic_DNA.
DR   RefSeq; WP_011182998.1; NC_006055.1.
DR   RefSeq; YP_053341.1; NC_006055.1.
DR   AlphaFoldDB; Q6F216; -.
DR   SMR; Q6F216; -.
DR   STRING; 265311.Mfl101; -.
DR   EnsemblBacteria; AAT75457; AAT75457; Mfl101.
DR   GeneID; 2897800; -.
DR   KEGG; mfl:Mfl101; -.
DR   PATRIC; fig|265311.5.peg.102; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_2_14; -.
DR   OMA; HIECFDN; -.
DR   Proteomes; UP000006647; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..588
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000227444"
FT   DOMAIN          12..89
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          194..229
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   588 AA;  68928 MW;  818F062896B35FFA CRC64;
     MELKNKVSNL PSKPGCYLYL NKDKHVIYVG KAKNLKKRVS SYFDRAQNLK TTRLVREIAD
     LEYFVVSNEK ESLLLEENLI KKYRPKYNVL LNDDKAYPYI IITNEKDPTY KYVRKLDKKA
     FRSFGPLPIG SNARETLITL QRLFPLRRCK GNLGKPCLHY FIGQCSGACF KEVNKEYYQE
     QIKRVDNFFK GNINEVKTLL TNQMHKAAEN LQFEEAQRIK EQIISLDFTT TKQNVEFKSQ
     TDVDVISYFI EDEKIAIVTL FYRSGKLLFK DEHIQLYFEQ DITDLIDSFM SQIYDKNILP
     DKIIVDNEVE LFDLNEKYKS ISTHPIKEDE KIIYKLATEN AQEAIRKSKI STTINIGNEN
     ELLLELQEKA NLQKEPYRLE MFDISNIGNE FIVGSCVVYI NGKPARNEFR KYNIESKFTS
     DYDRLKEMLY RRFQKALIEK RMLPDLIIMD GGIIQIHAAK EIINALGLSE IQVIGLVKDE
     HHNTSFLIDT NEEQVIIKDK PKLFNWLSSI QVRVDEYAKS GFRKKQNNSF LKSDLEQIEG
     LGKKRIQDLF KKFNTINEIE SADQEELFKI LKNKKALDNL NIYLKNRK