ID   UVRC_METBF              Reviewed;         519 AA.
AC   Q468S9;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=Mbar_A2709;
OS   Methanosarcina barkeri (strain Fusaro / DSM 804).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=269797;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Fusaro / DSM 804;
RX   PubMed=16980466; DOI=10.1128/jb.00810-06;
RA   Maeder D.L., Anderson I., Brettin T.S., Bruce D.C., Gilna P., Han C.S.,
RA   Lapidus A., Metcalf W.W., Saunders E., Tapia R., Sowers K.R.;
RT   "The Methanosarcina barkeri genome: comparative analysis with
RT   Methanosarcina acetivorans and Methanosarcina mazei reveals extensive
RT   rearrangement within methanosarcinal genomes.";
RL   J. Bacteriol. 188:7922-7931(2006).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CP000099; AAZ71613.1; -; Genomic_DNA.
DR   RefSeq; WP_011307654.1; NC_007355.1.
DR   AlphaFoldDB; Q468S9; -.
DR   SMR; Q468S9; -.
DR   STRING; 269797.Mbar_A2709; -.
DR   PRIDE; Q468S9; -.
DR   EnsemblBacteria; AAZ71613; AAZ71613; Mbar_A2709.
DR   GeneID; 3624457; -.
DR   KEGG; mba:Mbar_A2709; -.
DR   eggNOG; arCOG04753; Archaea.
DR   HOGENOM; CLU_014841_3_2_2; -.
DR   OMA; HIECFDN; -.
DR   OrthoDB; 5341at2157; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   SOS response.
FT   CHAIN           1..519
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000264985"
FT   DOMAIN          9..87
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          191..226
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   519 AA;  60100 MW;  F5434A60FC7F1239 CRC64;
     MIDLEALPHL PGCYLFKNEE GTVIYVGKAK DLKKRVSSYF QKREHDPKTA SLIEAVRGFD
     FIVTNTEVEA FLLENTLIKK HWPRYNILLK DSKRYACIHL TEEKFPRIRL SRKKADNGSF
     FGPFVSAKER DYIFEVVRKT FQLRTCKKMP KRACLRYHIA ACSGPCIGAI SAEDYAEKVK
     KAASVLKGNI RELIESMEKD MRELASRQQF EQAMALRDEI AALEYLQEKQ NMERQKKHNE
     DILNYIVRDD TVYLMLFKVY KGTLEDKQDY VFAFGENFLE EFLVQYYSEN EPPEELILPE
     PLEESLVDFL SHVKGTKVKV TVPKQGEKKE LLDLALKNVE IGFFGDRKKL EALQSKLSLP
     KLPNVIECFD ISHLSGTSTV GSMVQFRGGR PDKHNYRRFK IESVEGIDDF ASIAEVVRRR
     YSRLLEDKHD LPDLIIIDGG KGQLSSAFQE LRKLKVRVPL ISIAKREEEI YVPGIKSPLP
     IKKEEKASLF VQEIRDEAHR FAITYNRLLR QKSMIPKND