ID   UVRC_METMP              Reviewed;         527 AA.
AC   Q6LZA1;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=MMP0728;
OS   Methanococcus maripaludis (strain S2 / LL).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanococcaceae; Methanococcus.
OX   NCBI_TaxID=267377;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S2 / LL;
RX   PubMed=15466049; DOI=10.1128/jb.186.20.6956-6969.2004;
RA   Hendrickson E.L., Kaul R., Zhou Y., Bovee D., Chapman P., Chung J.,
RA   Conway de Macario E., Dodsworth J.A., Gillett W., Graham D.E., Hackett M.,
RA   Haydock A.K., Kang A., Land M.L., Levy R., Lie T.J., Major T.A.,
RA   Moore B.C., Porat I., Palmeiri A., Rouse G., Saenphimmachak C., Soell D.,
RA   Van Dien S., Wang T., Whitman W.B., Xia Q., Zhang Y., Larimer F.W.,
RA   Olson M.V., Leigh J.A.;
RT   "Complete genome sequence of the genetically tractable hydrogenotrophic
RT   methanogen Methanococcus maripaludis.";
RL   J. Bacteriol. 186:6956-6969(2004).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BX950229; CAF30284.1; -; Genomic_DNA.
DR   RefSeq; WP_011170672.1; NC_005791.1.
DR   AlphaFoldDB; Q6LZA1; -.
DR   SMR; Q6LZA1; -.
DR   STRING; 267377.MMP0728; -.
DR   EnsemblBacteria; CAF30284; CAF30284; MMP0728.
DR   GeneID; 2762069; -.
DR   KEGG; mmp:MMP0728; -.
DR   PATRIC; fig|267377.15.peg.745; -.
DR   eggNOG; arCOG04753; Archaea.
DR   HOGENOM; CLU_014841_3_2_2; -.
DR   OMA; HIECFDN; -.
DR   OrthoDB; 5341at2157; -.
DR   BioCyc; MMAR267377:MMP_RS03810-MON; -.
DR   Proteomes; UP000000590; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..527
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000264984"
FT   DOMAIN          9..87
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          191..226
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   527 AA;  61368 MW;  95BC45CF477EF3F8 CRC64;
     MINISDIPKN PGCYIYKNES GTVIYVGKAK NLKKRVSSYF NKKNHDPKTE KLVKSIYEME
     FIVTDNEVEA LILENTLIKK YSPKYNIDLK DSKNYAYIYI SEENFPRIGI SRNKSKKGKF
     YGPFTSAKER DYVLDVLKKT FKIRSCKNMH KRPCLRHHIK NCTAPCSGDI TSKDYLNQIK
     KAEHILKGNI DSLIHELKNE MNEKSKNLQF EEALLIREEI NAIERLKTRQ NVKRDVKYNE
     DVISILEKSG KLHIMVFNVL KGTLFDRKYF EFDYTENFFE EFLIQYYSEN DVPSEIIISE
     LPKNLEEDNN EYSSDALLEY LSKKKGSKVA FKIPKQGEKK QLLDLAIKNL EIYVNGNEIK
     VQSLKNKLML DKSPNIIECF DISHLSGTST VGSVVQFRNG KPDKKNYRRF KIKTVSGIDD
     FKSISEVVFR RYSKLLEENL ELPDLIIIDG GKGQLSSAFS ELRKLKLKIP LISIAKREEE
     IYTPGIENPL PIKKNEKASL FIQEIRDEAH RFAINYNRLL RKKELIK