ID   UVRC_METST              Reviewed;         598 AA.
AC   Q2NGT2;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=Msp_0572;
OS   Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 /
OS   MCB-3).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanosphaera.
OX   NCBI_TaxID=339860;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3;
RX   PubMed=16385054; DOI=10.1128/jb.188.2.642-658.2006;
RA   Fricke W.F., Seedorf H., Henne A., Kruer M., Liesegang H., Hedderich R.,
RA   Gottschalk G., Thauer R.K.;
RT   "The genome sequence of Methanosphaera stadtmanae reveals why this human
RT   intestinal archaeon is restricted to methanol and H2 for methane formation
RT   and ATP synthesis.";
RL   J. Bacteriol. 188:642-658(2006).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CP000102; ABC56971.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q2NGT2; -.
DR   SMR; Q2NGT2; -.
DR   STRING; 339860.Msp_0572; -.
DR   EnsemblBacteria; ABC56971; ABC56971; Msp_0572.
DR   KEGG; mst:Msp_0572; -.
DR   eggNOG; arCOG00873; Archaea.
DR   eggNOG; arCOG04753; Archaea.
DR   HOGENOM; CLU_014841_3_2_2; -.
DR   OMA; HIECFDN; -.
DR   Proteomes; UP000001931; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..598
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000264986"
FT   DOMAIN          11..91
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          195..230
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   598 AA;  69341 MW;  02097B4255B603BB CRC64;
     MKLKTPDEVP QKPGVYIMHN KEDEVIYVGK AKKLKSRLQS YFRDEDKLDR PKTQFLMRHF
     SYFEYILTNT EKEALILEAN LIKKYRPHYN ISLKDGKQYP YIKITNEDFP RIYITRNIVN
     DKASYYGPYT DSTHARAFID FLNKNFQIRT CKHMDGPCLN YQIKQCSAPC VNYISQEEYN
     RNIRRVKLLL QGKYKTTIKK LKKDMNRYAK NMEFEKAAML RDQIDTIKIT LEKQNIQPNQ
     DVNQDIIGFD HNNEEAAVVI LSVRSGKTNK KDDLVLKGIK GFSDKQIRTE FIKQYYSTAP
     LPDEIILEDD IEDKDVIVEW LEEKANHKIK ITVATDGHYI TLIKIAKKNA HISLTENTKE
     EENPLLTLEK YLNLPRLPYH IEAFDISNIS GIYAVASMVV FENGKPAKKM YRKFKMNTPG
     PNDFAMMKEV ITRRYSHISP NNTNNTSDSL SIHPDLVLID GGKGQLGMAV DVFKKLNITD
     VPLAGLAKKF EEVYLPGQTN PIILPRQSSA LHLLQYVRDE SHRFAITFHR KLRSKAFTKS
     ILDDIPGVGK KRKQALLTHF ESLDNIYNAS FDEICQVKGI NQKLAKTIYE TLKEDKKE