ID   UVRC_MOOTA              Reviewed;         613 AA.
AC   Q2RLU8;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=Moth_0256;
OS   Moorella thermoacetica (strain ATCC 39073 / JCM 9320).
OC   Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
OC   Thermoanaerobacteraceae; Moorella group; Moorella.
OX   NCBI_TaxID=264732;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39073 / JCM 9320;
RX   PubMed=18631365; DOI=10.1111/j.1462-2920.2008.01679.x;
RA   Pierce E., Xie G., Barabote R.D., Saunders E., Han C.S., Detter J.C.,
RA   Richardson P., Brettin T.S., Das A., Ljungdahl L.G., Ragsdale S.W.;
RT   "The complete genome sequence of Moorella thermoacetica (f. Clostridium
RT   thermoaceticum).";
RL   Environ. Microbiol. 10:2550-2573(2008).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CP000232; ABC18591.1; -; Genomic_DNA.
DR   RefSeq; WP_011391800.1; NC_007644.1.
DR   RefSeq; YP_429134.1; NC_007644.1.
DR   AlphaFoldDB; Q2RLU8; -.
DR   SMR; Q2RLU8; -.
DR   STRING; 264732.Moth_0256; -.
DR   EnsemblBacteria; ABC18591; ABC18591; Moth_0256.
DR   KEGG; mta:Moth_0256; -.
DR   PATRIC; fig|264732.11.peg.272; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_2_9; -.
DR   OMA; HIECFDN; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   SOS response.
FT   CHAIN           1..613
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000264912"
FT   DOMAIN          12..89
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          199..234
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   613 AA;  68956 MW;  52BB1C8CDCDBA864 CRC64;
     MDLEEKLARL PDHPGVYIMH DANGAIIYVG KAASLRNRVR SYFRGQHQPR TQAMVSHVAD
     FEYILTDNEV EALILECNLI KQHRPRYNVS LKDDKSYPYI KITTQEDFPR IQITRSVTRD
     GSRYFGPYTS AGSLKETLKL LRGLFPIRTC RDTPLQPRSR PCLNAHIGRC LAPCAGQVDR
     ETYREAVDNV IMFLEGRHTA LVKELKEQME AAAARLEFEK AARLRDQLRA VQEVCEKQKL
     AAASGEDADA IAFAREGEAA LGLIFFSRGG KVIGRDHFFL TGSEGLSRGE VMAALLKEYY
     SRGVEIPPEI LLHDEPEDAA TIASWLSRLR GGRVNLRVPK RGTKLKLLRL VHENAVSLLQ
     EHLLTRRRQE EGSRAALLEL QEILELPRLP RRMEAYDISN FQGSSQVGAM AVFVDGRPLP
     SAYRRFQIKT VRGPNDFASL QEVLSRRFRR AAEQDPHFAD LPDFVLIDGG LGQLHAARET
     MEAMGVGYIP TFGLAKEEEL LFRVGTSEPI RLPRESKALQ ILQHLRDEVH RFAITYHRQK
     REKTAYRSVL DDIPGVGPKR KKALLRHFGS VAAISKATLE DLLAVEGMNR TVAARILAGL
     GRRSDGEDST GSP