ID   UVRC_MYCMS              Reviewed;         584 AA.
AC   Q6MTU8;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=MSC_0297;
OS   Mycoplasma mycoides subsp. mycoides SC (strain PG1).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=272632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PG1;
RX   PubMed=14762060; DOI=10.1101/gr.1673304;
RA   Westberg J., Persson A., Holmberg A., Goesmann A., Lundeberg J.,
RA   Johansson K.-E., Pettersson B., Uhlen M.;
RT   "The genome sequence of Mycoplasma mycoides subsp. mycoides SC type strain
RT   PG1T, the causative agent of contagious bovine pleuropneumonia (CBPP).";
RL   Genome Res. 14:221-227(2004).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; BX293980; CAE76938.1; -; Genomic_DNA.
DR   RefSeq; NP_975296.1; NC_005364.2.
DR   AlphaFoldDB; Q6MTU8; -.
DR   SMR; Q6MTU8; -.
DR   STRING; 272632.MSC_0297; -.
DR   EnsemblBacteria; CAE76938; CAE76938; MSC_0297.
DR   KEGG; mmy:MSC_0297; -.
DR   PATRIC; fig|272632.4.peg.317; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_2_14; -.
DR   OMA; HIECFDN; -.
DR   Proteomes; UP000001016; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..584
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000227447"
FT   DOMAIN          12..89
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          194..229
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   584 AA;  68670 MW;  CC192B75387F692C CRC64;
     MSLKQQVDLL PNKPGCYLFF NKDNDVIYVG KAKNLKKRVS TYFNKAYNIK TTRLVREITD
     LKYFIVDNEK ESLLLEKNLI KKYHPKYNVL LNDDKTYPYI IITNQKDPMY KYVRKYDKKA
     LKNYGPLPIG SNARSILLTL QRLFPLRMCQ GNLNKPCLYY HLNQCSGACF KQVDPSYYEY
     QIKQVDKFFK GEINQVKQTL VKQMQKASDN LQFEQAQRIK DQITSLDFIT AKQNVDIVTN
     KNIDVVNYEI NQDKICFVIL FYRLGQLTYK DEYIQNYEGQ NLSELFNSYL QQIYQKNIYP
     DVLLIPNEIE LLDLDQNLLE FSSYSLNKQD DVFIKLAKQN AIDSLNKSVI SHNVNSGDEI
     EILEQLKQIS NASKYLKRIE VFDISNIYSQ FITGACIVYI NAKPIRNEFR KYNIDPSYTS
     DFSRMKFMLE KRFLKQIKEK EQLPDLVIVD GGIIQIHAAK EVLNKLNLKI DVIGLSKDDH
     HKTRYLIDIF EQTIDIKNFK KLYNFLTSLQ IRVDEYAKSG FRKKYHNQLN DQILLIKGVG
     KKTNLKLYKH FKTIDNIKNA SFDELNKVIN NKKITNLIIS NLNK